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Advanced Healthcare Materials


Advanced Healthcare Materials


Advanced Material Series 1. Aufl.

von: Ashutosh Tiwari

177,99 €

Verlag: Wiley
Format: EPUB
Veröffentl.: 09.05.2014
ISBN/EAN: 9781118773680
Sprache: englisch
Anzahl Seiten: 560

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Beschreibungen

<p><b>Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications</b></p> <p>Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. <i>Advanced Healthcare Materials</i> highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology.</p> <p>The senior researchers from global knowledge centers have written topics including:</p> <ul> <li>State-of-the-art of biomaterials for human health</li> <li>Micro- and nanoparticles and their application in biosensors</li> <li>The role of immunoassays</li> <li>Stimuli-responsive smart nanoparticles</li> <li>Diagnosis and treatment of cancer</li> <li>Advanced materials for biomedical application and drug delivery</li> <li>Nanoparticles for diagnosis and/or treatment of Alzheimers disease</li> <li>Hierarchical modelling of elastic behavior of human dental tissue</li> <li>Biodegradable porous hydrogels</li> <li>Hydrogels in tissue engineering, drug delivery, and wound care</li> <li>Modified natural zeolites</li> <li>Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane</li> <li>Polyhydroxyalkanoate-based biomaterials</li> <li>Biomimetic molecularly imprinted polymers</li> </ul>
<p>Preface xvii<br /> <br /> <b>1</b> <b>Stimuli-Responsive Smart Nanoparticles for Biomedical Application 1<br /> </b><i>Arnab De, Sushil Mishra and Subho Mozumdar</i><i><br /> <br /> </i>1.1 A Brief Overview of Nanotechnology 2<br /> <br /> 1.2 Nanoparticulate Delivery Systems 3<br /> <br /> 1.3 Delivery Systems 4<br /> <br /> 1.4 Polymers for Nanoparticle Synthesis 11<br /> <br /> 1.5 Synthesis of Nanovehicles 15<br /> <br /> 1.6 Dispersion of Preformed Polymers 16<br /> <br /> 1.7 Emulsion Polymerization 20<br /> <br /> 1.8 Purification of Nanoparticle 22<br /> <br /> 1.9 Drying of Nanoparticles 24<br /> <br /> 1.10 Drug Loading 25<br /> <br /> 1.11 Drug Release 26<br /> <br /> 1.12 Conclusion 27<br /> <br /> References 27<br /> <br /> <b>2</b> <b>Diagnosis and Treatment of Cancer—Where We Are</b> <b>and Where We Have to Go! 35<br /> </b><i>R</i><i>a</i><i>jiv</i> <i>Lochan Gaur and Richa Srivastava<br /> <br /> </i>2.1 Cancer Pathology 36<br /> <br /> 2.2 Cancer Diagnosis 37<br /> <br /> 2.3 Treatment 41<br /> <br /> Conclusion 42<br /> <br /> References 42<br /> <br /> <b>3</b> <b>Advanced Materials for Biomedical Application and</b> <b>Drug Delivery 47<br /> </b><i>Salam</i> <i>J.J.</i> <i>T</i><i>itinchi</i><i>,</i> <i>M</i><i>ayank</i> <i>P</i><i>.</i> <i>Singh, Hanna S. Abbo and Ivan R. Green<br /> <br /> </i>3.1 Introduction 48<br /> <br /> 3.2 Anticancer Drug Entrapped Zeolite Structures as Drug Delivery Systems 48<br /> <br /> 3.3 Mesoporous Silica Nanoparticles and Multifunctional Magnetic Nanoparticles in Biomedical Applications 52<br /> <br /> 3.4 BioMOFs: Metal-Organic Frameworks for Biological and Medical Applications 64<br /> <br /> 3.5 Conclusions 75<br /> <br /> References 75<br /> <br /> <b>4</b> <b>Nanoparticles for Diagnosis and/or Treatment of</b> <b>Alzheimer’s Disease 85<br /> </b><i>S.G.</i> <i>Antimisiaris, S. Mourtas, E. Markoutsa, A. Skouras,</i> <i>and K. Papadia<br /> <br /> </i>4.1 Introduction 85<br /> <br /> 4.2 Nanoparticles 86<br /> <br /> 4.3 Physiological Factors Related with Brain-Located Pathologies: Focus on AD 96<br /> <br /> 4.4 Current Methodologies to Target AD-Related Pathologies 110<br /> <br /> 4.5 Nanoparticles for Diagnosis of AD 136<br /> <br /> 4.6 Nanoparticles for Therapy of AD 146<br /> <br /> 4.7 Summary of Current Progress and Future Challenges 160<br /> <br /> Acknowledgments 161<br /> <br /> References 161<br /> <br /> <b>5 </b> <b>Novel Biomaterials for Human Health: Hemocompatible Polymeric Micro-and Nanoparticles and Their</b> <b>Application in Biosensor 179<br /> </b><i>C</i><i>hong</i> <i>Sun</i><i>, Xiaobo Wang, Chun Mao and Jian Shen<br /> <br /> </i>5.1 Introduction 179</p> <p>5.2 Design and Preparation of Hemocompatible Polymeric Micro- and Nanoparticles 181</p> <p>5.3 The Biosafety and Hemocompatibility Evaluation System for Polymeric Micro- and Nanoparticles 183</p> <p>5.4 Construction of Biosensor for Direct Detection in Whole Blood 188<br /> <br /> 5.5 Conclusion and Prospect 194<br /> <br /> References 195<br /> <br /> <b>6</b> <b>The Contribution of Smart Materials and Advanced Clinical Diagnostic Micro-Devices on the Progress and Improvement</b> <b>of Human Health Care 199<br /> </b><i>T</i><i>eles</i><i>,</i> <i>F.R.R. and Fonseca, L.P.<br /> <br /> </i>6.1 Introduction 200<br /> <br /> 6.2 Physiological Biomarkers as Targets in Clinical Diagnostic Bioassays 202</p> <p>6.3 Biosensors 205</p> <p>6.4 Advanced Materials and Nanostructures for Health Care Applications 217</p> <p>6.5 Applications of Micro-Devices to Some Important Clinical Pathologies 223<br /> <br /> 6.6 Conclusions and Future Prospects 227<br /> <br /> Acknowledgment 227<br /> <br /> References 228<br /> <br /> <b>7</b> <b>Hierarchical Modeling of Elastic Behavior of Human Dental</b> <b>Tissue Based on Synchrotron Diffraction Characterization 233<br /> </b><i>Tan</i><i>Sui and Alexander M. Korsunsky<br /> <br /> </i>7.1  Introduction 233<br /> <br /> 7.2 Experimental Techniques 236<br /> <br /> 7.3 Model Formulation 238<br /> <br /> 7.4 Experimental Results and Model Validation 245<br /> <br /> 7.5 Discussion 251<br /> <br /> 7.6 Conclusions 255<br /> <br /> Acknowledgments 256<br /> <br /> Appendix 256<br /> <br /> References 260<br /> <br /> <b>8</b> <b>Biodegradable Porous Hydrogels 263<br /> </b><i>Martin Pradny, Miroslav Vetrik, Martin Hruby</i> <i>and Jiri Michalek<br /> <br /> </i>8.1 Introduction 263<br /> <br /> 8.2 Methods of Preparation of Porous Hydrogels 265<br /> <br /> 8.3 Hydrogels Crosslinked With Degradable Crosslinkers 271<br /> <br /> 8.4 Hydrogels Degradable in the Main Chain 276<br /> <br /> 8.5 Conclusions 281<br /> <br /> Acknowledgments 281<br /> <br /> References 283<br /> <br /> <b>9</b> <b>Hydrogels: Properties, Preparation, Characterization and Biomedical Applications in Tissue Engineering, Drug Delivery</b> <b>and Wound Care 289<br /> </b><i>Mohammad Sirousazar, Mehrdad Forough, Khalil Farhadi,</i> <i>Y</i><i>asama</i><i>n</i> <i>Shaabani and Rahim Molaei<br /> <br /> </i>9.1 Introduction 289<br /> <br /> 9.2 Types of Hydrogels 290<br /> <br /> 9.3 Properties of Hydrogels 295<br /> <br /> 9.4 Preparation Methods of Hydrogels 299<br /> <br /> 9.5 Characterization of Hydrogels 305<br /> <br /> 9.6 Biomedical Applications of Hydrogels 308<br /> <br /> 9.7 Hydrogels for Wound Management 319<br /> <br /> 9.8 Recent Developments on Hydrogels 337<br /> <br /> 9.9 Conclusions 340<br /> <br /> References 341<br /> <br /> <b>10</b> <b>Modified Natural Zeolites—Functional Characterization</b> <b>and Biomedical Application 353<br /> </b><i>J</i><i>e</i><i>la</i> <i>Mili</i>æ, <i>Aleksandra Dakovi</i>æ, Danina Krajišnik <i>and George E. Rottinghaus</i><i><br /> </i><b><i><br /> </i></b>10.1 Introduction 354<br /> <br /> 10.2 Surfactant Modified Zeolites (SMZs) 359<br /> <br /> 10.3 Minerals as Pharmaceutical Excipients 366<br /> <br /> 10.4 SMZs for Pharmaceutical Application 372<br /> <br /> 10.5 Conclusions 389<br /> <br /> Acknowledgement 390<br /> <br /> References 390<br /> <br /> <b>11</b> <b>Supramolecular Hydrogels Based on Cyclodextrin Poly(Pseudo)Rotaxane for New and Emerging</b> <b>Biomedical Applications 397<br /> </b><i>Jin</i><i>Huang, Jing Hao, Debbie P. Anderson and</i> <i>Peter R. Chang</i><i><br /> </i><b><i><br /> </i></b>11.1 Introduction 398<br /> <br /> 11.2 Fabrication of Cyclodextrin Poly(pseudo)rotaxane-Based Hydrogels 400<br /> <br /> 11.3 Stimulus-Response Properties of Cyclodextrin Poly(pseudo)rotaxane Based Hydrogels 409<br /> <br /> 11.4 Nanocomposite Supramolecular Hydrogels 413<br /> <br /> 11.5 Biomedical Application of Cyclodextrin Poly(pseudo)rotaxane-Based Hydrogels 420<br /> <br /> 11.6 Conclusions and Prospects 425<br /> <br /> References 425<br /> <br /> <b>12</b> <b>Polyhydroxyalkanoate-Based Biomaterials for Applications</b><b>in Biomedical Engineering 431<br /> </b><i>Chenghao Zhu and Qizhi Chen</i><br /> <b><i><br /> </i></b>12.1 Introduction<br /> <br /> 12.2 Synthesis of PHAs 433<br /> <br /> 12.3 Processing and its Influence on the Mechanical Properties of PHAs 435<br /> <br /> 12.4 Mechanical Properties of PHA Sheets/Films 436<br /> <br /> 12.5 PHA-Based Polymer Blends 439<br /> <br /> 12.6 Summary 451<br /> <br /> References 451<br /> <b><br /> 13</b> <b>Biomimetic Molecularly Imprinted Polymers as Smart</b> <b>Materials and Future Perspective in Health Care 457<br /> </b><i>Mohammad Reza Ganjali, Farnoush Faridbod</i> <i>and Parviz Norouzi</i><i><br /> </i><b><i><br /> </i></b>13.1 Molecularly Imprinted Polymer Technology 458<br /> <br /> 13.2 Synthesis of MIPs 458<br /> <br /> 13.3 Application of MIPs 463<br /> <br /> 13.4 Biomimetic Molecules 464<br /> <br /> 13.5 MIPs as Receptors in Bio-Molecular Recognition 465<br /> <br /> 13.6 MIPs as Sensing Elements in Sensors/Biosensors 466<br /> <br /> 13.7 MIPs as Drug Delivery Systems 467<br /> <br /> 13.8 MIPs as Sorbent Materials in Separation Science 475<br /> <br /> 13.9 Future Perspective of MIP Technologies 480<br /> <br /> 13.10 Conclusion 480<br /> <br /> References 480<br /> <br /> <b>14</b> <b>The Role of Immunoassays in Urine Drug Screening 485<br /> </b><i>Niina</i> <i>J.</i> <i>Ronkainen and Stanley L. Okon</i><i><br /> </i><b><i><br /> </i></b>14.1 Introduction 486<br /> <br /> 14.2 Urine and Other Biological Specimens 489<br /> <br /> 14.3 Immunoassays 491<br /> <br /> 14.4 Drug Screening with Immunoassays 504<br /> <br /> 14.5 Immunoassay Specificity: False Negative and False Positive Test Results 507<br /> <br /> 14.6 Confirmatory Secondary Testing Using Chromatography Instruments 510<br /> <br /> Conclusion 513<br /> <br /> References</p>
<p>“Although they claim in the Preface that this book is written for university students and researchers from diverse backgrounds, I believe having read the majority of the scientific aspects of the work it really expects the reader to have a very thorough knowledge of polymer chemistry at the nanometer level of particle or pore size and suggest this book is aimed at the researchers in the pharmaceutical industry or academics in pharmaceutical chemistry research rather than researchers into biomaterials.”  (<i>Scope</i>, 1 February 2014)</p> <p> </p>
<p><b>Ashutosh Tiwari</b> is an Associate Professor at the Biosensors and Bioelectronics Centre, Linköping University, Sweden; Editor-in-Chief, <i>Advanced Materials Letters</i>; Secretary General, International Association of Advanced Materials; a materials chemist and also a docent in applied physics at Linköping University, Sweden. He has published more than 350 articles, patents, and conference proceedings in the field of materials science and technology and has edited/authored more than fifteen books on the advanced state-of-the-art of materials science. He is a founding member of the Advanced Materials World Congress and the Indian Materials Congress.</p>
<p><b>Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications</b></p> <p>Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. <i>Advanced Healthcare Materials</i> highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology.</p> <p>The senior researchers from global knowledge centers have written topics including:</p> <ul> <li>State-of-the-art of biomaterials for human health</li> <li>Micro- and nanoparticles and their application in biosensors</li> <li>The role of immunoassays</li> <li>Stimuli-responsive smart nanoparticles</li> <li>Diagnosis and treatment of cancer</li> <li>Advanced materials for biomedical application and drug delivery</li> <li>Nanoparticles for diagnosis and/or treatment of Alzheimers disease</li> <li>Hierarchical modelling of elastic behavior of human dental tissue</li> <li>Biodegradable porous hydrogels</li> <li>Hydrogels in tissue engineering, drug delivery, and wound care</li> <li>Modified natural zeolites</li> <li>Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane</li> <li>Polyhydroxyalkanoate-based biomaterials</li> <li>Biomimetic molecularly imprinted polymers</li> </ul> <p><b>Audience</b><br /> This book has been written for a large readership including researchers, industry engineers, and students from diverse backgrounds such as chemistry, materials science, physics, pharmacy, medical science, biotechnology, and biomedical engineering.</p>

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