Details

Cell-Penetrating Peptides


Cell-Penetrating Peptides

Design, Development and Applications
1. Aufl.

von: Makoto Oba, Yosuke Demizu

142,99 €

Verlag: Wiley-VCH
Format: EPUB
Veröffentl.: 30.11.2022
ISBN/EAN: 9783527836000
Sprache: englisch
Anzahl Seiten: 416

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Beschreibungen

<b>Cell-Penetrating Peptides</b> <p><b>The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs.</b> <p>In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell. <p><i>Cell-Penetrating Peptides: Design, Development, and Applications</i> provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture. <ul><li>Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles </li> <li>Presents the chemical and biological characteristics of CPP action <i>in vitro and in vivo</i></li> <li>Describes the structure and design principles of both synthetic and naturally occurring CPPs</li> <li>Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials</li></ul> <p><i>Cell-Penetrating Peptides: Design, Development, and Applications</i> is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.
Introduction<br> <br> PART 1: DESGIN OF CPPS<br> Classification<br> Tat<br> Penetration<br> Guanidino transporter<br> Arg-rich peptides<br> Transportan<br> Hydrophobic peptides<br> Foldamers<br> <br> PART 2: MECHANISM OF CPPS<br> Peptide structure<br> Cellular uptake<br> Endosomal escape<br> Pharmacokinetics<br> <br> PART 3: DELIVERY TOOLS<br> Drug delivery<br> Peptide & protein delivery<br> Nucleic acid delivery<br> Polymeric micelles<br> Lipid-based nanoparticles<br> <br> PART 4: APPLICATIONS<br> Oral delivery<br> Intranasal delivery<br> Clinical trials<br> CPPs in Plants<br>
<p><i><b>Makoto Oba</b>, Professor of Medical Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan. He has authored more than 100 scientific publications and has received several awards, including the Incentive Award in Synthetic Organic Chemistry. </i> <p><i><b>Yosuke Demizu</b>, Head of Division of Organic Chemistry, National Institute of Health Sciences (NIHS), Japan. He has published more than 150 scientific articles and is the recipient of several awards, such as the Japanese Peptide Society Award for Young Investigators.</i>
<p><b>The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs.</b> <p>In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell. <p><i>Cell-Penetrating Peptides: Design, Development, and Applications</i> provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture. <ul><li>Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles </li> <li>Presents the chemical and biological characteristics of CPP action <i>in vitro and in vivo</i></li> <li>Describes the structure and design principles of both synthetic and naturally occurring CPPs</li> <li>Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials</li></ul> <p><i>Cell-Penetrating Peptides: Design, Development, and Applications</i> is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.

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