Details

Amide Bond Activation

Concepts and Reactions
1. Aufl.

von: Michal Szostak
151,99 €
Verlag:	Wiley-VCH
Format:	EPUB
Veröffentl.:	18.10.2022
ISBN/EAN:	9783527830268
Sprache:	englisch
Anzahl Seiten:	528

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Beschreibungen

Titelbeschreibung

Amide Bond Activation Comprehensive resource on the pivotal role of the amide bond in organic synthesis This book provides the reader with insight into the advances that have taken place in the field of amide bond activation. It focuses on both the fundamental structural properties of the amide bond and the synthetic reactions mediated by transition-metals. By discussing amide bond activation in terms of modern organic synthesis, the reader is provided with a thorough overview of the area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds. Sample topics discussed within the work include: <ul><li> Cross-coupling of amides</li> <li> Amide bond activation by twisting and nitrogen pyramidalization</li> <li> Electrophilic amide bond functionalization</li> <li> Transition metal-catalyzed radical reactions of amides</li> <li> Amide bond esterification, hydrolysis and transamidation</li> <li> Classical bridged lactams and anomeric amides</li> <li> Computational studies of amide C-N bond activation</li> <li>Cross-coupling of esters by C-O activation</li></ul> The book is immensely valuable to synthetic chemists in academia and the pharmaceutical industry who wish to gain an in-depth understanding of the concept of amide bond activation.

Inhaltsverzeichnis

1) Bridged Lactams as Model Systems for Amidic Distortion 2) Modification of Amidic Resonance Through Heteroatom Substitution at Nitrogen - Anomeric Amides 3) Amide Bond Activation by Twisting and Nitrogen Pyramidalization 4) Transition-Metal-Free Reactions of Amides by Tetrahedral Intermediates 5) Electrophilic Amide Bond Functionalisation 6) Transamidation of Carboxamides and Amide Derivatives: Mechanistic Insights, Concepts, and Reactions 7) Amide Bond Esterification and Hydrolysis 8) Activation of Amide C-N Bonds by Nickel Catalysis 9) Pd-NHC Catalysis in Cross-Coupling of Amides 10) Cross-Coupling of Amides through Decarbonylation 11) Transition Metal-Catalyzed Radical Reactions of Amides 12) Weinreb Amide as a Multifaceted Directing Group in C-H Activation 13) Computational Studies of Amide C-N Bond Activation 14) Esters as Viable Acyl Cross-Coupling Electro-Philes 15) Cross-Coupling of Aromatic Esters by Decarbonylation

Autorenportrait

Michal Szostak is currently a Professor of Chemistry at Rutgers University, Newark, USA. He received his Ph.D. from the University of Kansas (USA) with Prof. Jeffrey Aubé in 2009. After postdoctoral stints at Princeton University (USA) with Prof. David MacMillan and at the University of Manchester (UK) with Prof. David Procter, in 2014, he joined the faculty at Rutgers University. His research group is focused on the development of new synthetic methodology based on transition-metal-catalysis, amide bond activation, conformational preferences of amides, transition-metal-mediated free-radical chemistry, C-H activation, and application to the synthesis of biologically-active molecules.

Back cover copy

Comprehensive resource on the pivotal role of the amide bond in organic synthesis This book provides the reader with insight into the advances that have taken place in the field of amide bond activation. It focuses on both the fundamental structural properties of the amide bond and the synthetic reactions mediated by transition-metals. By discussing amide bond activation in terms of modern organic synthesis, the reader is provided with a thorough overview of the area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds. Sample topics discussed within the work include: <ul><li> Cross-coupling of amides</li> <li> Amide bond activation by twisting and nitrogen pyramidalization</li> <li> Electrophilic amide bond functionalization</li> <li> Transition metal-catalyzed radical reactions of amides</li> <li> Amide bond esterification, hydrolysis and transamidation</li> <li> Classical bridged lactams and anomeric amides</li> <li> Computational studies of amide C-N bond activation</li> <li>Cross-coupling of esters by C-O activation</li></ul> The book is immensely valuable to synthetic chemists in academia and the pharmaceutical industry who wish to gain an in-depth understanding of the concept of amide bond activation.