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<p>Preface xiii</p> <p><b>1 Extracellular Matrix Hydrogels from Decellularized Tissues for Biological and Biomedical Applications 1</b><br /><i>Brendan C. Jones, Nicola Elvassore, Paolo De Coppi, and Giovanni G. Giobbe</i></p> <p>1.1 Introduction to Hydrogels 1</p> <p>1.2 Key Features and Functions of the Extracellular Matrix in Homeostasis and Development 6</p> <p>1.3 Extracellular Matrix-Based Hydrogels Derived from Decellularization of Organs 8</p> <p>1.4 Commercially Available Products 18</p> <p><b>2 Collagen-Based Systems to Mimic the Extracellular Environment 23</b><br /><i>Umber Cheema and Vivek Mudera</i></p> <p>2.1 Cells in Tissues 23</p> <p>2.2 Collagen in Tissues 24</p> <p>2.3 Controlling Collagen Architecture 26</p> <p>2.4 Engineering Collagen Scaffolds 29</p> <p>2.5 Conclusions 33</p> <p><b>3 Designing Elastin-Like Recombinamers for Therapeutic and Regenerative Purposes 37</b><br /><i>José Carlos Rodríguez-Cabello, Sara Escalera, Diana Juanes-Gusano, Mercedes Santos, and Alessandra Girotti</i></p> <p>3.1 Introduction 37</p> <p>3.2 ELR-Based Hydrogels in Tissue Engineering 39</p> <p>3.3 ELR-Based Hydrogels for Drug Delivery 48</p> <p>3.4 Future Remarks 56</p> <p><b>4 Enzyme-Assisted Hydrogel Formation for Tissue Engineering Applications 63</b><br /><i>Sílvia Pérez-Rafael, Eva Ramon, and Tzanko Tzanov</i></p> <p>4.1 Introduction 63</p> <p>4.2 Enzymatically Cross-Linked Hydrogels 66</p> <p>4.3 Supramolecular Enzyme-Driven Hydrogelation 75</p> <p>4.4 Conclusions 81</p> <p><b>5 Hierarchical Peptide- and Protein-Based Biomaterials: From Molecular Structure to Directed Self-assembly and Applications 97</b><br /><i>Yinchen Yuan, Yejiao Shi, and Helena S. Azevedo</i></p> <p>5.1 Introduction 97</p> <p>5.2 Molecular Design/Selection of Building Blocks for Hierarchical Self-assembly 98</p> <p>5.3 Hierarchical Assembly Through Environmental Manipulation 108</p> <p>5.4 Techniques for the Characterization of Hierarchically Organized Biomaterials 113</p> <p>5.5 Application of Hierarchical Self-assembling Peptide- and Protein-Based Biomaterials in Tissue Regeneration 117</p> <p>5.6 Conclusions 120</p> <p><b>6 Short Peptide Hydrogels for Biomedical Applications 127</b><br /><i>Priyadarshi Chakraborty, Lihi Adler-Abramovich, and Ehud Gazit</i></p> <p>6.1 Introduction 127</p> <p>6.2 Short Peptide Hydrogels 128</p> <p>6.3 Biomedical Applications of Short Peptide Hydrogels 129</p> <p>6.4 Conclusions and Outlook 139</p> <p><b>7 Supramolecular Assemblies of Glycopeptides as Mimics of the Extracellular Matrix 149</b><br /><i>Diana Soares da Costa, Alexandra Brito, Rui L. Reis, and Iva Pashkuleva</i></p> <p>7.1 Introduction 149</p> <p>7.2 Glycoproteins and Proteoglycans in the ECM 150</p> <p>7.3 Design of Self-assembling Peptide--Saccharide Conjugates 151</p> <p>7.4 Supramolecular Systems Generated by Interfacial Co-assembly 154</p> <p>7.5 Conclusions 155</p> <p><b>8 Supramolecular Assemblies for Cancer Diagnosis and Treatment 161</b><br /><i>Shuang Liu and Bing Xu</i></p> <p>8.1 Introduction 161</p> <p>8.2 Cancer Diagnosis 162</p> <p>8.3 Cancer Treatment 173</p> <p>8.4 Future Perspectives 189</p> <p><b>9 Polyzwitterionic Hydrogels as Wound Dressing Materials 195</b><br /><i>Konstans Ruseva and Elena Vassileva</i></p> <p>9.1 Polyzwitterions 195</p> <p>9.2 Wound Management and Wound Dressings 197</p> <p>9.3 PZIs as Dressings Materials for AcuteWounds 198</p> <p>9.4 PZI as Dressings for Chronic Wounds Management 206</p> <p>9.5 Conclusions 212</p> <p><b>10 Hyaluronan-Based Hydrogels as Modulators of Cellular Behavior 217</b><br /><i>Sara Amorim, Rui L. Reis, and Ricardo A. Pires</i></p> <p>10.1 Introduction 217</p> <p>10.2 Biological Relevance of Hyaluronan 218</p> <p>10.3 Hyaluronan-Based Systems for Biomedical Applications 220</p> <p>10.4 Conclusion and Future Remarks 226</p> <p><b>11 Hydrogel Fibers Produced via Microfluidics 233</b><br /><i>Kongchang Wei, Claudio Toncelli, René M. Rossi, and Luciano F. Boesel</i></p> <p>11.1 Introduction to Microfluidics and Microfluidic Wet Spinning 233</p> <p>11.2 Fabrication of Chips for Microfluidic Wet Spinning 237</p> <p>11.3 Biomedical Applications of Hydrogel Fibers Produced via Microfluidics 242</p> <p>11.4 Hydrogel Optical Fibers 257</p> <p>11.5 Conclusions 263</p> <p><b>12 Embedding Hydrogels into Microfluidic Chips: Vascular Transport Analyses and Drug Delivery Optimization 275</b><br /><i>Ana M. Martins, Alexander B. Cook, Martina Di Francesco, Maria Grazia Barbato, Sayanti Brahmachari, Martina Pannuzzo, and Paolo Decuzzi</i></p> <p>12.1 Introduction: Microfluidic Chips for Modeling Human Diseases and Developing New Therapies 275</p> <p>12.2 Hydrogels to Mimic the Extracellular Matrix (ECM) 276</p> <p>12.3 Fabrication of Microfluidic Chips 277</p> <p>12.4 Applications of Microfluidic Chips in Biophysical Transport Analysis 282</p> <p>12.5 Nanoparticle Transport Analyses 284</p> <p>12.6 Computer Simulations of Nanoparticle and Cell Transport 285</p> <p>12.7 Conclusions and Future Directions 287</p> <p><b>13 Multifunctional Granular Hydrogels for Tissue-Specific Repair 295</b><br /><i>Rui J. Almeida, Ana Fernandes, Vítor M. Gaspar, and João F. Mano</i></p> <p>13.1 Introduction 295</p> <p>13.2 Granular Hydrogels -- Functional Features and Design 297</p> <p>13.3 Granular Hydrogels for Tissue-Specific Repair 308</p> <p>13.4 Conclusions and Future Perspectives 317</p> <p><b>14 Injectable Hydrogels as a Stem Cell Delivery Platform for Wound Healing 323</b><br /><i>Qian Xu, Sigen A., and Wenxin Wang</i></p> <p>14.1 Wound Healing 323</p> <p>14.2 Stem Cells for Skin Wound Healing 328</p> <p>14.3 Injectable Hydrogel Dressing as a Delivery Platform 331</p> <p>Index 357</p>

<p><b><i>Ricardo A. Pires</b> has a background in materials engineering. Currently, he is an Assistant Researcher at 3B’s (Biomaterials, Biodegradables and Biomimetics) Research Group at the University of Minho, Braga/Guimarães, Portugal, and the European Institute of Excellence on Tissue Engineering and Regenerative Medicine at the University of Minho. He is also a member of the Portuguese Government Associate Laboratory ICVS/3B’s. His research interests include supramolecular hydrogels, 3D disease models, pathological peptide/protein aggregation, and bionanomaterials.</i></p> <p><b><i>Iva Pashkuleva</b> has a background in chemistry. Currently, she is a Principal Researcher at 3B’s (Biomaterials, Biodegradables and Biomimetics) Research Group at University of Minho, Braga/Guimarães, Portugal, and the European Institute of Excellence on Tissue Engineering and Regenerative Medicine at University of Minho. She is also a member of the Portuguese Government Associate Laboratory ICVS/3B’s. Her research interests include glycan supramolecular systems, self-assembly, and cell-surface interactions.</i> <p><b><i>Rui L. Reis</b> is a world recognized expert in Tissue Engineering and Regenerative Medicine (TERM). He is the Director of 3B’s (Biomaterials, Biodegradables and Biomimetics) Research Group and Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells at the University of Minho, Braga/Guimarães, Portugal. He is the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine and Director of the Portuguese Government Associate Laboratory ICVS/3B’s. He is well known for his pioneer works on the use of natural polymers for TERM.</i>

<p><b>Comprehensive resource presenting a thorough overview of the biomedical applications of hydrogels</B></p> <p>This book provides an overview of the development and applications of the clinically relevant hydrogels that are used particularly in tissue engineering, regenerative medicine, and drug delivery. Taking a multidisciplinary approach, it goes through the material from chemistry, materials science, biology, medicine, nanotechnology, and bioengineering points of view. Sample topics covered by the three well-qualified editors include: <ul><li>The design, functions, and developments of hydrogels</li> <li>Proteins and polysaccharides that mimic extracellular matrix</li> <li>Generation and applications of supramolecular hydrogels</li> <li>Design and functions of cell encapsulation systems</li></ul> <p><i>Multifunctional Hydrogels for Biomedical Applications</i> is a useful all-in-one reference work for materials scientists, polymer chemists, and bioengineers which provides a comprehensive, contemporary understanding of hydrogels and their applications targeting a wide variety of pathologies.

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