Details

Biochemical Engineering

A Textbook for Engineers, Chemists and Biologists
2nd Completely Revised and Enlarged Edition

von: Shigeo Katoh, Jun-ichi Horiuchi, Fumitake Yoshida
70,99 €
Verlag:	Wiley-VCH
Format:	PDF
Veröffentl.:	02.02.2015
ISBN/EAN:	9783527684991
Sprache:	englisch
Anzahl Seiten:	328

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Beschreibungen

Titelbeschreibung

Completely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co-author Jun-ichi Horiuchi, who is one of the leading experts in the field. The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self-study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions. An excellent, comprehensive introduction to the principles of biochemical engineering.

Inhaltsverzeichnis

Preface Nomenclature PART I: Basic Concepts and Principles INTRODUCTION Background and Scope Dimensions and Units Intensive and Extensive Properties Equilibria and Rates Batch vs. Continuous Operation Material Balance Energy Balance ELEMENTA OF PHYSICAL TRANSFER PROCESSES Introduction Heat Conduction and Molecular Diffusion Fluid Flow and Momentum Transfer Laminar vs. Turbulent Flow Transfer Phenomena in Turbulent Flow Film Coefficients of Heat and Mass Transfer CHEMICAL AND BIOCHEMICAL KINETICS Introduction Fundamental Reaction Kinetics CELL KINETICS Introduction Cell Growth Growth Phases in Batch Culture Factors Affecting Rates of Cell Growth Cell Growth in Batch Fermentors and Continuous Stirred Tank Fermentor (CSTF) PART II: Unit Operations and Apparatus for Bio-Systems HEAT TRANSFER Introduction Overall Coefficients U and Film Coefficients h Mean Temperature Difference Estimation of Film Coefficients h Estimation of Overall Coefficients U MASS TRANSFER Introduction Overall Coefficients K and Film Coefficients k of Mass Transfer Types of Mass Transfer Equipment Models for Mass Transfer at the Interface Liquid Phase Mass Transfer with Chemical Reactions Correlations for Film Coefficients of Mass Transfer Performance of Packed Column BIOREACTORS Introduction Some Fundamental Concepts Bubbling Gas-Liquid Reactors Mechanically Stirred Tanks Gas Dispersion in Stirred Tanks Bubble Columns Airlift Reactors Packed-Bed Reactors Microreactors MEMBRANE PROCESSES Introduction Dialysis Ultrafiltration Microfiltration Reverse Osmosis Membrane Modules CELL-LIQUID SEPARATION AND CELL DISRUPTION Introduction Conventional Filtration Microfiltration Centrifugation Cell Disruption STERILIZATION Introduction Kinetics of Thermal Death of Cells Batch Heat Sterilization of Culture Media Continuous Heat Sterilization of Culture Media Sterilizing Filtration ADSORPTION AND CHROMATOGRAPHY Introduction Equilibria in Adsorption Rates of Adsorption into Adsorbent Particles Single- and Multi-Stage Processes for Adsorption Adsorption in Fixed Beds Separation by Chromatography Biorecognition Assay PART III: Practical Aspects in Bioengineering FERMENTOR ENGINEERING Introduction Stirrer Power Requirements for Non-Newtonian Liquids Heat Transfer in Fermentors Gas-Liquid Mass Transfer in Fermentors Criteria for Scaling-Up Fermentors Modes of Fermentor Operation Fermentors for Animal Cell Culture INSTRUMENTATION AND CONTROL OF BIOPROCESSES Introduction Instrumentation of Bioprocesses Control of Bioprocesses Advanced Control of Bioprocesses DOWNSTREAM OPERATIONS IN BIOPROCESSES Introduction Separation of Microorganisms by Filtration and Microfiltration Separation by Chromatography Separation in Fixed Beds Sanitation in Downstream Processes MEDICAL DEVICES Introduction Blood and Its Circulation Oxygenation of Blood Artificial Kidney Bioartificial Liver Appendix Index

Rezension

“I would like to congratulate the authors and publishers for producing such an excellent book. I found it easy to comprehend and well structured. The book has been written with an assumption of minimal prior knowledge of chemical engineering . . .In conclusion, the book constitutes not only a very good starting point for a novice reader but also a comprehensive refresher course for someone who is already familiar with the field.” (Institution of Chemical Engineers, 1 September 2015)

Autorenportrait

Prof. Shigeo Katoh is now Professor emeritus at Kobe University, Japan. He was - after his retirement - a full professor at Hanyang University at Korea and a visiting professor at Cheng Kung University at Taiwan. Before his retirement, he was Head of the Bioengineering Laboratory at Kobe University, Japan. He holds a PhD in Chemical Engineering from the University of Kyoto, Japan. Prof. Katoh is an enthusiastic lecturer in Biochemical Engineering, Bioseparation Engineering and Immunotechnology. He is an outstanding expert in biochemical engineering and has published numerous papers in this field. Prof. Jun-ichi Horiuchi is Director of the Instrumental Analysis Center at the Kitami Institute of Technology (Japan) since 2010. He obtained his Master degree in Engineering from Hokkaido University and thereafter went to the Science University of Tokyo, where he received his PhD in biotechnology in 1995. Afterwards he spent several years as research engineer at Toyo Engineering Corporation, before he became Professor at the Kitami Institute of Technology in 1998. Prof. Horiuchis research interests are in the field of bioprocess control and optimization and up to now he published over 60 peer reviewed jounal contributions, 12 patents and 9 book contributions. Prof. em. Fumitake Yoshida was one of the world's most respected chemical engineers. Most recently he was professor emeritus of chemical engineering at Kyoto University and well beyond his retirement he continued to be a visiting lecturer at universities around the world. He conducted research on various mass transfer operations, gas-liquid systems in particular, investigating their applications in bioengineering and medical technology. Yoshida received his BS and PhD degrees in engineering from Kyoto University. Among his many awards and citations was election to the National Academy of Engineering of the United States in 1979 for his leadership in chemical, biochemical, and biomedical engineering in Japan.

Back cover copy

Completely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co-author Jun-ichi Horiuchi, who is one of the leading experts in the field. The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self-study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions. An excellent, comprehensive introduction to the principles of biochemical engineering.