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Biomimetic Approaches for Biomaterials Development

1. Aufl.

von: Joao F. Mano
171,99 €
Verlag:	Wiley-VCH
Format:	EPUB
Veröffentl.:	08.02.2013
ISBN/EAN:	9783527652297
Sprache:	englisch
Anzahl Seiten:	606

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Titelbeschreibung

Biomimetics, in general terms, aims at understanding biological principles and applying them for the development of man-made tools and technologies. This approach is particularly important for the purposeful design of passive as well as functional biomaterials that mimic physicochemical, mechanical and biological properties of natural materials, making them suitable, for example, for biomedical devices or as scaffolds for tissue regeneration. The book comprehensively covers biomimetic approaches to the development of biomaterials, including: an overview of naturally occurring or nature inspired biomaterials; an in-depth treatment of the surface aspects pivotal for the functionality; synthesis and self-assembly methods to prepare devices to be used in mineralized tissues such as bone and teeth; and preparation of biomaterials for the controlled/ sustained release of bioactive agents. The last part reviews the applications of bioinspired materials and principles of design in regenerative medicine such as in-situ grown bone or cartilage as well as the biomimetic techniques for soft tissue engineering. The comprehensive scope of this book makes it a must-have addition to the bookshelf of everyone in the fields of Materials Science/Engineering, Nanotechnologies / Nanosciences, Medical Sciences, Biochemistry, Polymer Chemistry, and Biomedical Engineering.

Inhaltsverzeichnis

Preface XVII List of Contributors XXI Part I Examples of Natural and Nature-Inspired Materials 1 1 Biomaterials from Marine-Origin Biopolymers 3 Tiago H. Silva, Ana R.C. Duarte, Joana Moreira-Silva, Joao F. Mano, and Rui L. Reis 1.1 Taking Inspiration from the Sea 3 1.2 Marine-Origin Biopolymers 6 1.3 Marine-Based Tissue Engineering Approaches 12 1.4 Conclusions 18 2 Hydrogels from Protein Engineering 25 Midori Greenwood-Goodwin and Sarah C. Heilshorn 2.1 Introduction 25 2.2 Principles of Protein Engineering 26 2.3 Structural Diversity and Applications of Protein-Engineered Hydrogels 32 2.4 Development of Biomimetic Protein-Engineered Hydrogels for Tissue Engineering Applications 39 2.5 Conclusions and Future Perspective 48 3 Collagen-Based Biomaterials for Regenerative Medicine 55 Christophe Helary and Abhay Pandit 3.1 Introduction 55 3.2 Collagens In Vivo 56 3.3 Collagen In Vitro 59 3.4 Collagen Hydrogels 59 3.5 Collagen Sponges 65 3.6 Multichannel Collagen Scaffolds 66 3.7 What Tissues Do Collagen Biomaterials Mimic? (see Table 3.1) 66 3.8 Concluding Remarks 70 4 Silk-Based Biomaterials 75 Silvia Gomes, Isabel B. Leonor, Joao F. Mano, Rui L. Reis, and David L. Kaplan 4.1 Introduction 75 4.2 Silk Proteins 76 4.3 Mechanical Properties 82 4.4 Biomedical Applications of Silk 84 4.5 Final Remarks 87 5 Elastin-like Macromolecules 93 Rui R. Costa, Laura Martin, Joao F. Mano, and Jose C. Rodríguez-Cabello 5.1 General Introduction 93 5.2 Materials Engineering – an Overview on Synthetic and Natural Biomaterials 94 5.3 Elastin as a Source of Inspiration for Nature-Inspired Polymers 94 5.4 Nature-Inspired Biosynthetic Elastins 99 5.5 ELRs as Advanced Materials for Biomedical Applications 103 5.6 Conclusions 110 6 Biomimetic Molecular Recognition Elements for Chemical Sensing 117 Justyn Jaworski 6.1 Introduction 117 6.2 Theory of Molecular Recognition 123 6.3 Molecularly Imprinted Polymers 129 6.4 Supramolecular Chemistry 134 6.5 Biomolecular Materials 140 6.6 Summary and Future of Biomimetic-Sensor-Coating Materials 151 Part II Surface Aspects 157 7 Biology Lessons for Engineering Surfaces for Controlling Cell–Material Adhesion 159 Ted T. Lee and André’s J. García 7.1 Introduction 159 7.2 The Extracellular Matrix 159 7.3 Protein Structure 160 7.4 Basics of Protein Adsorption 161 7.5 Kinetics of Protein Adsorption 162 7.6 Cell Communication 164 7.7 Cell Adhesion Background 166 7.8 Integrins and Adhesive Force Generation Overview 167 7.9 Adhesive Interactions in Cell, and Host Responses to Biomaterials 170 7.10 Model Systems for Controlling Integrin-Mediated Cell Adhesion 170 7.11 Self-Assembling Monolayers (SAMs) 171 7.12 Real-World Materials for Medical Applications 172 7.13 Bio-Inspired, Adhesive Materials: New Routes to Promote Tissue Repair and Regeneration 174 7.14 Dynamic Biomaterials 176 8 Fibronectin Fibrillogenesis at the Cell–Material Interface 189 Marco Cantini, Patricia Rico, and Manuel Salmeron-Sanchez 8.1 Introduction 189 8.2 Cell-Driven Fibronectin Fibrillogenesis 189 8.3 Cell-Free Assembly of Fibronectin Fibrils 195 8.4 Material-Driven Fibronectin Fibrillogenesis 202 9 Nanoscale Control of Cell Behavior on Biointerfaces 213 E. Ada Cavalcanti-Adam and Dimitris Missirlis 9.1 Nanoscale Cues in Cell Environment 213 9.2 Biomimetics of Cell Environment Using Interfaces 216 9.3 Cell Responses to Nanostructured Materials 227 9.4 The Road Ahead 233 References 234 10 Surfaces with Extreme Wettability Ranges for Biomedical Applications 237 Wenlong Song, Natalia M. Alves, and Joao F. Mano 10.1 Superhydrophobic Surfaces in Nature 237 10.2 Theory of Surface Wettability 239 10.3 Fabrication of Extreme Water-Repellent Surfaces Inspired by Nature 241 10.4 Applications of Surfaces with Extreme Wettability Ranges in the Biomedical Field 245 10.5 Conclusions 254 11 Bio-Inspired Reversible Adhesives for Dry and Wet Conditions 259 Aranzazu del Campo and Juan Pedro Fernandez-Blazquez 11.1 Introduction 259 11.2 Gecko-Like Dry Adhesives 260 11.3 Bioinspired Adhesives for Wet Conditions 268 11.4 The Future of Bio-Inspired Reversible Adhesives 270 12 Lessons from Sea Organisms to Produce New Biomedical Adhesives 273 Elise Hennebert, Pierre Becker, and Patrick Flammang 12.1 Introduction 273 12.2 Composition of Natural Adhesives 274 12.3 Recombinant Adhesive Proteins 281 12.4 Production of Bio-Inspired Synthetic Adhesive Polymers 284 12.5 Perspectives 288 Part III Hard and Mineralized Systems 293 13 Interfacial Forces and Interfaces in Hard Biomaterial Mechanics 295 Devendra K. Dubey and Vikas Tomar 13.1 Introduction 295 13.2 Hard Biological Materials 298 13.4 Summary 308 14 Nacre-Inspired Biomaterials 313 Gisela M. Luz and Joao F. Mano 14.1 Introduction 313 14.2 Structure of Nacre 316 14.3 Why Is Nacre So Strong? 318 14.4 Strategies to Produce Nacre-Inspired Biomaterials 320 14.5 Conclusions 328 15 Surfaces Inducing Biomineralization 333 Natalia M. Alves, Isabel B. Leonor, Helena S. Azevedo, Rui. L. Reis, and Joao. F. Mano 15.1 Mineralized Structures in Nature: The Example of Bone 333 15.2 Learning from Nature to the Research Laboratory 336 15 Surfaces Inducing Biomineralization 333 Natalia M. Alves, Isabel B. Leonor, Helena S. Azevedo, Rui. L. Reis, and Joao. F. Mano 15.1 Mineralized Structures in Nature: The Example of Bone 333 15.2 Learning from Nature to the Research Laboratory 336 15.3 Smart Mineralizing Surfaces 343 15.4 In Situ Self-Assembly on Implant Surfaces to Direct Mineralization 345 15.5 Conclusions 348 16 Bioactive Nanocomposites Containing Silicate Phases for Bone Replacement and Regeneration 353 Melek Erol, Jasmin Hum, and Aldo R. Boccaccini 16.1 Introduction 353 16.2 Nanostructure and Nanofeatures of the Bone 354 16.3 Nanocomposites-Containing Silicate Nanophases 356 16.4 Final Considerations 372 Part IV Systems for the Delivery of Bioactive Agents 381 17 Biomimetic Nanostructured Apatitic Matrices for Drug Delivery 383 Norberto Roveri and Michele Iafisco 17.1 Introduction 383 17.2 Biomimetic Apatite Nanocrystals 384 17.3 Biomedical Applications of Biomimetic Nanostructured Apatites 390 17.4 Biomimetic Nanostructured Apatite as Drug Delivery System 394 17.5 Adsorption and Release of Proteins 402 17.6 Conclusions and Perspectives 18 Nanostructures and Nanostructured Networks for Smart Drug Delivery 417 Carmen Alvarez-Lorenzo, Ana M. Puga, and Angel Concheiro 18.1 Introduction 417 18.2 Stimuli-Sensitive Materials 419 18.3 Stimuli-Responsive Nanostructures and Nanostructured Networks 428 18.4 Concluding Remarks 449 19 Progress in Dendrimer-Based Nanocarriers 459 Joaquim M. Oliveira, Joao F. Mano, and Rui L. Reis 19.1 Fundamentals 459 19.2 Applications of Dendrimer-Based Polymers 460 19.3 Final Remarks 467 Part V Lessons from Nature in Regenerative Medicine 471 20 Tissue Analogs by the Assembly of Engineered Hydrogel Blocks 473 Shilpa Sant, Daniela F. Coutinho, Nasser Sadr, Rui L. Reis, and Ali Khademhosseini 20.1 Introduction 473 20.2 Tissue/Organ Heterogeneity In Vivo 474 20.3 Hydrogel Engineering for Obtaining Biologically Inspired Structures 477 20.4 Assembly of Engineered Hydrogel Blocks 485 20.5 Conclusions 488 21 Injectable In-Situ-Forming Scaffolds for Tissue Engineering 495 Da Yeon Kim, Jae Ho Kim, Byoung Hyun Min, and Moon Suk Kim 21.1 Introduction 495 21.2 Injectable In-Situ-Forming Scaffolds Formed by Electrostatic Interactions 496 21.3 Injectable In-Situ-Forming Scaffolds Formed by Hydrophobic Interactions 497 21.4 Immune Response of Injectable In-Situ-Forming Scaffolds 500 21.5 Injectable In-Situ-Forming Scaffolds for Preclinical Regenerative Medicine 500 21.6 Conclusions and Outlook 501 22 Biomimetic Hydrogels for Regenerative Medicine 503 Iris Mironi-Harpaz, Olga Kossover, Eran Ivanir, and Dror Seliktar 22.1 Introduction 503 22.2 Natural and Synthetic Hydrogels 503 22.3 Hydrogel Properties 505 2.4 Engineering Strategies for Hydrogel Development 506 22.5 Applications in Biomedicine 508 23 Bio-inspired 3D Environments for Cartilage Engineering 515 Jose Luis Gomez Ribelles 23.1 Articular Cartilage Histology 515 23.2 Spontaneous and Forced Regeneration in Articular Cartilage 517 23.3 What Can Tissue Engineering Do for Articular Cartilage Regeneration? 517 23.4 Cell Sources for Cartilage Engineering 519 23.5 The Role and Requirements of the Scaffolding Material 524 23.6 Growth Factor Delivery In Vivo 528 23.7 Conclusions 528 24 Soft Constructs for Skin Tissue Engineering 537 Simone S. Silva, Joao F. Mano, and Rui L. Reis 24.1 Introduction 537 24.2 Structure of Skin 537 24.3 Current Biomaterials in Wound Healing 539 24.4 Wound Dressings and Their Properties 545 24.5 Biomimetic Approaches in Skin Tissue Engineering 546 24.6 Final Remarks 549 Acknowledgments 552 List of Abbreviations 552 References 553 Index 559

Autorenportrait

Jo?o F. Mano (CEng, PhD, DSc) is an Associate Professor at the Polymer Engineering Department, University of Minho, Portugal, and principal investigator at the 3B's research group - Biomaterials, Biodegradables and Biomimetics. He is the former director of the Master's Program in Biomedical Engineering at the University of Minho. His current research interests include the development of new materials and concepts for biomedical applications, especially aimed at being used in tissue engineering and in drug delivery systems. In particular, he has been developing biomaterials and surfaces that can react to external stimuli, or biomimetic and nanotechnology approaches to be used in the biomedical area. J.F. Mano authored more than 330 papers in international journals and three patents. He belongs to the editorial boards of 5 well-established international journals. J.F. Mano awarded the 'Stimulus to Excellence' by the Portuguese Minister for Science and Technology in 2005, the 'Materials Science and Technology Prize', attributed by the Federation of European Materials Societies in 2007 and the major 'BES innovation award' in 2010.

Back cover copy

Biomimetics, in general terms, aims at understanding biological principles and applying them for the development of man-made tools and technologies. This approach is particularly important for the purposeful design of passive as well as functional biomaterials that mimic physicochemical, mechanical and biological properties of natural materials, making them suitable, for example, for biomedical devices or as scaffolds for tissue regeneration. The book comprehensively covers biomimetic approaches to the development of biomaterials, including: an overview of naturally occurring or nature inspired biomaterials; an in-depth treatment of the surface aspects pivotal for the functionality; synthesis and self-assembly methods to prepare devices to be used in mineralized tissues such as bone and teeth; and preparation of biomaterials for the controlled/ sustained release of bioactive agents. The last part reviews the applications of bioinspired materials and principles of design in regenerative medicine such as in-situ grown bone or cartilage as well as the biomimetic techniques for soft tissue engineering. The comprehensive scope of this book makes it a must-have addition to the bookshelf of everyone in the fields of Materials Science/Engineering, Nanotechnologies / Nanosciences, Medical Sciences, Biochemistry, Polymer Chemistry, and Biomedical Engineering.