Details

Innovative Catalysis in Organic Synthesis


Innovative Catalysis in Organic Synthesis

Oxidation, Hydrogenation, and C-X Bond Forming Reactions
1. Aufl.

from: Pher G. Andersson

165,99 €

Publisher: Wiley-VCH
Format PDF
Published: 14.03.2012
ISBN/EAN: 9783527646616
Language: englisch
Number of pages: 374

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Descriptions

C-H, C-O, C-C, and C-Heteroatom bond forming processes by using metal-ligand approaches for the synthesis of organic compounds of<br> biological, pharmacological and organic nanotechnological utility are the key areas addressed in this book. Authored by a European team<br> of leaders in the field, it brings together innovative approaches for a variety of catalysis reactions and processes frequently applied in organic<br> synthesis into a handy reference work. It covers all major types of catalysis, including homogeneous, heterogeneous, and organocatalysis, as<br> well as mechanistic and computational studies. Special attention is paid to the improvements in efficiency and sustainability of important<br> catalytic processes, such as selective oxidations, hydrogenation, and cross-coupling reactions, and to their utilization in industry.<br> <br> The result is a valuable resource for advanced researchers in both academia and industry, as well as graduate students in organic chemistry<br> aiming for chemo-, regio- or stereoselective synthesis of organic compounds by using novel catalytic systems.<br>
FOREWORD <br> <br> PART I: Oxidation Reactions <br> <br> POLYOXOMETALATES AS HOMOGENEOUS OXIDATION CATALYSTS <br> Soluble Metal Oxides as Oxidation Catalysts <br> Homogeneous Oxidations with POMs Based Only on Mo(VI), W(VI), V(V) Addenda Ions <br> Homogeneous Oxidations with TMS-POMs <br> Conclusions <br> <br> BIOINSPIRED OXIDATIONS CATALYZED BY NONHEME IRON AND MANGANESE COMPLEXES <br> Introduction <br> Catalytic Oxidation of C = C Bonds by Nonheme Iron and Manganese Complexes<br> Catalytic Oxidation of C -<br> H Bonds by Nonheme Iron and Manganese Complexes<br> <br> THE FABULOUS DESTINY OF SULFENIC ACIDS<br> Introduction<br> Synthesis of Stable Sulfenic Acids<br> Generation of Transient Sulfenic Acids<br> Reactivity of Sulfenic Acids in the Preparation of Sulfoxides and Unsymmetrical Disulfides<br> Synthesis of Stable Sulfenate Anions<br> Generation of Transient Sulfenate Anions Leading to Sulfoxides<br> Conclusions<br> <br> SUSTAINABLE CATALYTIC OXIDATIONS WITH PEROXIDES <br> Introduction <br> Metal-Based Selective Oxidations <br> Biocatalytic Oxidations with Hydrogen Peroxide<br> Conclusions <br> <br> PART II: Hydrogenation and Reduction Reactions <br> <br> ASYMMETRIC HYDROGENATION OF DEHYDROAMINO ACID DERIVATIVES BY RH-CATALYSTS WITH CHIRAL MONODENTATE P-LIGANDS <br> Introduction <br> Chiral Monodentate Phosphorus Ligands in Asymmetric Hydrogenation <br> Catalyst Precursors <br> Mechanistic Insights <br> Formation of the MAC Adducts <br> Evolution of MAC-Adducts and Origin of Enantioselection <br> <br> RECENT ADVANCES IN THE SYNTHESIS AND CATALYTIC HYDROGENATION OF DEHYDROAMINO ACID DERIVATIVES AND BICYCLO[2.2.2]OCTENES <br> Introduction <br> Synthesis of DDAA Derivatives and Bicyclo[2.2.2]octenes <br> Ligands <br> Homogeneous Hydrogenation and Hydrogenolysis Reactions with Dehydroamino Acid Derivatives and Bicyclo[2.2.2]oct-7-enes over Nanocolloids-Modified Catalysts <br> Heterogeneous Catalysts for Hydrogenolysis of Bicyclo[2.2.2]oct-7-enes <br> Layered-Double Hydroxides as a Support for Rh(TPPTS)3 and Rh-(m-TPPTC)3 Homogeneous Catalysts <br> Conclusions <br> <br> IR-CATALYZED HYDROGENATION OF MINIMALLY FUNCTIONALIZED OLEFINS USING PHOSPHITE -<br> NITROGEN LIGANDS <br> Introduction <br> Application of Phosphite -<br> Nitrogen Ligands <br> Conclusions <br> <br> MODELING IN HOMOGENEOUS CATALYSIS: A TUTORIAL <br> Introduction <br> Molecular Modeling <br> Wave Function Theory, WFT <br> Density Functional Theory, DFT <br> Orbitals <br> Basis Sets <br> Solvation <br> Analyzing the Reaction Energies <br> Analyzing the Electronic Structure <br> <br> PART III: C -<br> C and C -<br> Hetero bond-Forming Reactions <br> <br> GOLDEN TIMES FOR ALLENES <br> Introduction <br> Cyclization of Hydroxyallenes <br> Cyclization of Aminoallenes <br> Cyclization of Thioallenes <br> Conclusion <br> <br> COPPER CATALYSIS IN ARENE AND HETEROARENE FUNCTIONALIZATION THROUGH<br> C -<br> H BOND ACTIVATION <br> Introduction <br> C -<br> C Bond-Forming Reactions <br> C -<br> N Bond-Forming Reactions <br> C -<br> O Bond-Forming Reactions<br> C -<br> Halogen Bond-Forming Reactions <br> <br> LIGATED ORGANOCUPRATES: AN A -<br> Z ROUTEMAP OF MECHANISM AND APPLICATION<br> Introduction <br> Accepted Mechanistic Proposals<br> Selective Applications in Privileged Copper(I) Catalysis <br> <br> RH-, AG-, AND CU-CATALYZED C -<br> N BOND FORMATION <br> Introduction <br> Historical Background <br> Copper- and Silver-Catalyzed C -<br> N Bond Formation <br> Rhodium-Catalyzed C -<br> N Bond Formation <br> Conclusions <br> <br> DEVELOPMENT OF THE ASYMMETRIC NOZAKI -<br> HIYAMA -<br> KISHI REACTION <br> Introduction <br> Development of a Catalytic Nozaki -<br> Hiyama -<br> Kishi Reaction <br> Catalytic Enantioselective Nozaki -<br> Hiyama -<br> Kishi Reaction <br> Application of Salen-Derived Ligands in the Enantioselective Nozaki -<br> Hiyama -<br> Kishi Reaction <br> Application of Oxazoline-Containing Ligands in the Catalytic Enantioselective Nozaki -<br> Hiyama -<br> Kishi Reaction <br> Application of Tethered Bis(8-quinolinato) Chromium Complexes in the Catalytic Enantioselective Nozaki -<br> Hiyama -<br> Kishi <br> Application of Chiral Spirocyclic Borate Ligands to the Catalytic Enantioselective Nozaki -<br> Hiyama -<br> Kishi Allylation <br> Applications of Catalytic Nozaki -<br> Hiyama -<br> Kishi Reaction in Total Synthesis <br> Conclusions <br> <br> CHIRAL IMIDATE LIGANDS: SYNTHESIS AND APPLICATIONS IN ASYMMETRIC CATALYSIS <br> Introduction <br> Cyclic Imidates <br> Synthesis of Imidates <br> Synthesis of Imidate Ligands <br> Synthesis of Imidate -<br> Copper (I) Complexes <br> Application of Chiral Imidate Ligands in Enantioselective Catalysis <br> Novel Synthetic Applications of Cyclic Imidates <br> Conclusions <br> <br> CATALYZED ORGANIC REACTIONS IN BALL MILLS <br> Introduction <br> Acid- or Base-Catalyzed Reactions <br> Organocatalytic Methods<br> Metal-Catalyzed Reactions <br> Conclusion and Perspective <br>
Pher G. Andersson holds a chair at the Department of Biochemistry and Organic Chemistry at Uppsala University, Sweden. He received his Ph.D. in 1991 and became a lecturer at Uppsala University in 1994 and a Professor in 1997. Among his many awards are the Bjurzons award (1992), the Oscar award (1995), the Junior Individual Grant for outstanding young researchers (1997), and the Astra Zeneca Research<br> Award in Organic Chemistry (2004). He was Chairman of the management committee for the COST D24 program 'Sustainable Chemical Processes: Stereoselective Transition Metal-Catalyzed Reactions' which ran from 2001-2006 and he was the Coordinator for the 'Excellent Nordic Chemistry Network'. Since 2011 he also holds a position as Honorary Research Professor at UKZN, South Africa. Pher Andersson<br> has authored more than 100 publications and edited the books 'Modern Reduction Methods' (Wiley-VCH, 2008) together with his former co-worker Ian Munslow and 'ridium Catalysis' (Springer, 2010). His research interests cover selective synthesis, asymmetric catalysis, and sustainable chemistry.
C-H, C-O, C-C, and C-Heteroatom bond forming processes by using metal-ligand approaches for the synthesis of organic compounds of<br> biological, pharmacological and organic nanotechnological utility are the key areas addressed in this book. Authored by a European team<br> of leaders in the field, it brings together innovative approaches for a variety of catalysis reactions and processes frequently applied in organic<br> synthesis into a handy reference work. It covers all major types of catalysis, including homogeneous, heterogeneous, and organocatalysis, as<br> well as mechanistic and computational studies. Special attention is paid to the improvements in efficiency and sustainability of important<br> catalytic processes, such as selective oxidations, hydrogenation, and cross-coupling reactions, and to their utilization in industry.<br> <br> The result is a valuable resource for advanced researchers in both academia and industry, as well as graduate students in organic chemistry<br> aiming for chemo-, regio- or stereoselective synthesis of organic compounds by using novel catalytic systems.<br>

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