Details

DNA-Pharmaceuticals


DNA-Pharmaceuticals

Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy
1. Aufl.

von: Martin Schleef

135,99 €

Verlag: Wiley-Blackwell
Format: PDF
Veröffentl.: 12.05.2006
ISBN/EAN: 9783527607006
Sprache: englisch
Anzahl Seiten: 275

DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.

Beschreibungen

With its focus on a completely novel class of pharmaceuticals, this book collates the hitherto scarce literature about DNA drug formulation keenly desired by biotechnologists, molecular biologists and pharmacists, as well as those working in the biotechnological and pharmaceutical industries.<br> As such, this volume presents a wide range of gene delivery systems needed for different therapeutic applications. It fills the gap between research and clinical trials and describes pharmaceutical fundamentals for the development of efficient DNA pharmaceuticals.
Preface<br> DNA Vaccines: an Overview<br> DNA as a Pharmaceutical: Regulatory Aspects<br> From Bulk to Delivery: Plasmid Manufacturing and Delivery<br> Minimized, CpG-Depleted and Methylated DNA Vectors: Towards Perfection in Nonviral Gene Therapy<br> Localized Nucleic Acid Delivery: a Discussion of Selected Methods<br> DNA Needle Injection<br> Needleless Jet Injection of Naked DNA von Nonviral in vivo Gene Transfer<br> Plasmid Inhalation: Delivery to the Airways<br> Hydrodynamic Gene Delivery<br> DNA Pharmaceuticals for Skin Diseases<br> Electrotransfection: an Overview<br> Electrogenetransfer in Clinical Applications<br> Cancer Inhibition in Mice after Systematic Application of Plasmid Driven Expression of Small Interfering RNAs<br> Index<br>
"It makes a valuable contribution to an important, topical and rapidly growing area of research and will be useful and of interest to students and professors, specialists and beginners in the field. I recommend it strongly, to libraries and individual researchers, in areas ranging all the way from biological chemistry to medicine." ChemMedChem<br>
Dr. Martin Schleef studied Biology at the Universities of Wurzburg and Bielefeld, Germany and holds a PhD from the University of Bielefeld.<br> Martin Schleef received post-doctoral training from the Institut Pasteur Paris, France. He joined QIAGEN GmbH, Hilden, Germany in 1994 and is co-founder and CEO of PlasmidFactory in Bielefeld since 2000.<br>
With its focus on a completely novel class of pharmaceuticals, this book collates the hitherto scarce literature about DNA drug formulation keenly desired by biotechnologists, molecular biologists and pharmacists, as well as those working in the biotechnological and pharmaceutical industries.<br> As such, this volume presents a wide range of gene delivery systems needed for different therapeutic applications. It fills the gap between research and clinical trials and describes pharmaceutical fundamentals for the development of efficient DNA pharmaceuticals.<br>

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