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<p>Dedication ix</p> <p>Preface xi</p> <p>Acknowledgements xiii</p> <p>List of Contributors xv</p> <p>1 Genomic and Epigenomic Biomarkers for Predictive Toxicity and Disease 1<br /> <i>Saura C. Sahu</i></p> <p>2 MicroRNAs as Non-invasive Biomarkers of Toxicity and Chemical Hazard: Genomic and Epigenomic Biomarkers of Toxicology and Disease 7<br /> <i>Gail M. Nelson and Brian N. Chorley</i></p> <p>3 EV (Extracellular Vesicle)-associated miRNAs as Biomarkers of Toxicity 37<br /> <i>Ryuichi Ono, Yusuke Yoshioka, Yusuke Furukawa, Mie Naruse, Makiko Kuwagata, Takahiro Ochiya, Satoshi Kitajima, and Yoko Hirabayashi</i></p> <p>4 Circulating miRNAs as Biomarkers of Toxic Heavy Metal Exposure 63<br /> <i>Alexandra N. Nail, Ana P. Ferragut Cardoso, Mayukh Banerjee, and J. Christopher States</i></p> <p>5 MicroRNA Biomarkers of Malignant Mesothelioma 89<br /> <i>Lijin Zhu, Fangfang Zhang, Min Zhang, Hailing Xia, Xiuyuan Yuan, and Yanan Gao</i></p> <p>6 Role of Non-coding RNAs in Innate Immune Responses Perturbed by Environmental Arsenic Exposure 101<br /> <i>Liz Saavedra Perez and Benjamin L. King</i></p> <p>7 Transcriptomics: Applications in Toxicology and Medicine 133<br /> <i>Pius Joseph Copyrighted Material</i></p> <p>8 Network Biology for Biomarker Discovery and Therapy in Cancer 163<br /> <i>Asim Bikas Das</i></p> <p>9 Epigenetic Biomarkers: Link to Maternal Exposure and Offspring Health Outcomes 185<br /> <i>Jairus Pulczinski, Moira Mccormick, Yuchen Sun, Musa Watfa, Robert YS Cheng, and Wan-Yee Tang</i></p> <p>10 The Role of Dynamic Epigenetic Changes in Modulating Homeostasis after Exposure to Low-dose Environmental Chemicals 213<br /> <i>Chongli Yuan, Jennifer L. Freeman, Junkai Xie, and Han Zhao</i></p> <p>11 Emerging Non-invasive Molecular Biomarkers for Early Cancer Detection 229<br /> <i>Jacob Sobota, Yingxue Zhang, Eid Alshammari,and Zhe Yang</i></p> <p>12 Aberrant DNA Methylation of Tumor Suppressor Genes and Oncogenes as Cancer Biomarkers 251<br /> <i>Eid Alshammari, Yingxue Zhang, Jacob Sobota, and Zhe Yang</i></p> <p>13 SMYD Protein Family as Promising Biomarkers for Cancer Diagnosis and Prognosis 273<br /> <i>Yingxue Zhang, Eid Alshammari, Jacob Sobota, and Zhe Yang</i></p> <p>14 Toward Precision Medicine: Epigenetic Alterations in Human Melanoma 309<br /> <i>Carmen Elena Condrat, Elena Codruta Dobrica, Sanda Maria Cretoiu, and Dragos Cretoiu</i></p> <p>15 Currents Trends and Future Perspectives in Our Epigenetic Signatures: What a Diet Can Trigger 333<br /> <i>Elena-Codruța Dobrică, Mihnea-Alexandru Găman, Matei-Alexandru Cozma, and Sanda Maria Cretoiu</i></p> <p>16 Genetic and Epigenetic Biomarkers of Organophosphate Compounds, Dialkyl Phosphate Exposure, and Their Relation to Biological Effects 363<br /> <i>David S. Hernández-Toledano and Libia Vega</i></p> <p>17 Genetic, Epigenetic, and Anatomical Factors in Agenesis and Development of Female Reproductive Tract 383<br /> <i>Tadaaki Nakajima, Tomomi Sato, and Taisen Iguchi</i></p> <p>18 Cause or Consequence: Epigenomic DNA Methylation Changes in Arsenic- Mediated in Vitro Transformation of Human Prostate Cells 395<br /> <i>B. Alex Merrick, Dhiral P. Phadke, Ruchir R. Shah, Deepak Mav, and Erik J. Tokar</i></p> <p>19 Epigenetic Regulation of Sex Determination and Toxicity in Nonmammalian Vertebrates 415<br /> <i>Genki Yamagishi, Taisen Iguchi, and Shinichi Miyagawa</i></p> <p>20 Characterization of Genomic and Epigenomic Biomarkers of Nanoparticle Toxicity Using the Zebrafish Model System 449<br /> <i>Athira Sairanthry Suku, Parayanthala Valappil Mohanan, and Jennifer L. Freeman</i></p> <p>Index 477</p>

<p><b>Saura C. Sahu, PhD,</b> is a former Research Chemist with the Division of Toxicology at the Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition at the United States Food and Drug Administration. </p>

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