Details
Hydrogen Sulfide
Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case StudiesWiley Series in Drug Discovery and Development 1. Aufl.
192,99 € |
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Verlag: | Wiley |
Format: | EPUB |
Veröffentl.: | 09.09.2022 |
ISBN/EAN: | 9781119799887 |
Sprache: | englisch |
Anzahl Seiten: | 592 |
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Beschreibungen
<b>HYDROGEN SULFIDE</b> <p><b>Covers H<sub>2</sub>S interactions, methods of detection and delivery in biological environments, and a wide range of applications</b> <p>Research on hydrogen sulfide (H<sub>2</sub>S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H<sub>2</sub>S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H<sub>2</sub>S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities. <p><i>Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies</i> provides the foundation required for understanding the fundamental chemical biology of H<sub>2</sub>S while highlighting the compound’s therapeutic potential and medicinal applications. This book covers key aspects of H<sub>2</sub>S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H<sub>2</sub>S in biological environments; and the therapeutic and medicinal uses of exogenous H<sub>2</sub>S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field. <ul><li>Provides approaches for delivering H<sub>2</sub>S with relevance to biological and therapeutic applications</li> <li>Describes complex interactions of H<sub>2</sub>S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species </li> <li>Summarizes advances in available tools to detect, measure, and modulate H<sub>2</sub>S levels in biological environments, such as real-time methods for H<sub>2</sub>S fluorescence imaging in live cell and animal systems </li> <li>Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action </li> <li>Includes in-depth case studies of different systems in which H<sub>2</sub>S plays an important role</li></ul> <p><i>Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies</i> is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.
<p>Preface xvii</p> <p>List of Contributors xix</p> <p><b>1 Fundamental and Biologically Relevant Chemistry of H<sub>2</sub>S and Related Species </b><b>1<br /></b><i>Jon M. Fukuto</i></p> <p>List of Abbreviations 1</p> <p>1.1 Introduction 2</p> <p>1.2 The Chemical Biology of H<sub>2</sub>S 2</p> <p>1.2.1 Basic Chemical Properties of H<sub>2</sub>S 3</p> <p>1.2.2 H<sub>2</sub>S Redox Chemistry 4</p> <p>1.2.3 Reactions of H<sub>2</sub>S with Metals/Metalloproteins 5</p> <p>1.2.4 H<sub>2</sub>S and Sulfheme Formation 6</p> <p>1.2.5 H<sub>2</sub>S and Heavy Metals 7</p> <p>1.3 H<sub>2</sub>S Reactions with Other Sulfur Species 8</p> <p>1.3.1 Sulfane Sulfur 8</p> <p>1.3.2 Generation of RSSH 8</p> <p>1.3.3 RSH Versus RSSH Comparison 9</p> <p>1.3.4 RSSH Interactions with Metals/Metalloproteins 14</p> <p>1.3.5 The Electrophilicity of RSSH 14</p> <p>1.3.6 Higher-Order Polysulfides 15</p> <p>1.3.7 RSSH Instability 16</p> <p>1.4 The Biochemical Utility of RSSH 17</p> <p>1.5 Summary/Conclusion 18</p> <p>References 18</p> <p><b>2 Signaling by Hydrogen Sulfide (H<sub>2</sub>S) and Polysulfides (H<sub>2</sub>S<i><sub>n</sub></i>) and the Interaction with Other Signaling Pathways </b><b>27<br /></b><i>Hideo Kimura</i></p> <p>List of Abbreviations 27</p> <p>2.1 Introduction 28</p> <p>2.2 Determination of the Endogenous Concentrations of H<sub>2</sub>S 29</p> <p>2.3 H<sub>2</sub>S and H<sub>2</sub>S<i><sub>n</sub> </i>as Signaling Molecules 31</p> <p>2.4 Crosstalk Between H<sub>2</sub>S and NO 32</p> <p>2.4.1 The Chemical Interaction of H<sub>2</sub>S and NO Produces H<sub>2</sub>S<i><sub>n</sub> </i>32</p> <p>2.4.2 Regulation of NO-Producing Enzymes by H<sub>2</sub>S and Vice Versa 33</p> <p>2.5 Cytoprotective Effect of H<sub>2</sub>S, H<sub>2</sub>S<i><sub>n</sub></i>, and H<sub>2</sub>SO<sub>3</sub> 34</p> <p>2.6 Energy Formation in Mitochondria with H<sub>2</sub>S 34</p> <p>2.7 <i>S</i>-Sulfurated Proteins and Bound Sulfane Sulfur in Cells 35</p> <p>2.8 Regulating the Activity of Target Proteins by H<sub>2</sub>S and H<sub>2</sub>S<i><sub>n</sub> </i>36</p> <p>2.8.1 S-Sulfuration by H<sub>2</sub>S 37</p> <p>2.8.2 S-Sulfuration by H<sub>2</sub>S<i><sub>n</sub> </i>38</p> <p>2.9 Perspectives 38</p> <p>Acknowledgments 40</p> <p>Author Disclosure Statement 41</p> <p>References 41</p> <p><b>3 Persulfides and Their Reactions in Biological Contexts </b><b>49<br /></b><i>Dayana Benchoam, Ernesto Cuevasanta, Matías N. Möller, and Beatriz Alvarez</i></p> <p>List of Abbreviations 49</p> <p>3.1 Persulfides Are Key Intermediates in Sulfur Metabolism and Signaling 49</p> <p>3.2 Persulfides Are Formed in Biological Systems through Different Pathways 51</p> <p>3.2.1 Disulfides Form Persulfides in the Presence of H<sub>2</sub>S 51</p> <p>3.2.2 Sulfenic Acids Can Also Form Persulfides by Reaction with H<sub>2</sub>S 53</p> <p>3.2.3 Other Persulfide Formation Pathways Involve Oxidation Products of H<sub>2</sub>S 53</p> <p>3.2.4 Some Sulfur Atoms for Persulfides Are Donated by Free Cysteine 54</p> <p>3.2.5 Trisulfides Are Also a Source of Persulfides 55</p> <p>3.2.6 Persulfides Can Be Prepared in the Lab 56</p> <p>3.3 Persulfides Are More Acidic Than Thiols 56</p> <p>3.4 Persulfides Are Stronger Nucleophiles Than Thiols 58</p> <p>3.5 Persulfidation Protects Against Irreversible Oxidation 60</p> <p>3.6 Persulfides Interact with Metals and Metalloproteins 61</p> <p>3.7 Persulfides Have Electrophilic Character in Both Sulfur Atoms 62</p> <p>3.8 Persulfides Are Efficient One-Electron Reductants 63</p> <p>3.9 Concluding Remarks 64</p> <p>References 64</p> <p><b>4 Hydrogen Sulfide, Reactive Nitrogen Species, and “The Joy of the Experimental Play” </b><b>77<br /></b><i>Miriam M. Cortese-Krott</i></p> <p>4.1 Introduction 77</p> <p>4.2 Basic Physicochemical Properties of Nitric Oxide and Its Biological Relevant Metabolites 79</p> <p>4.2.1 Nitric Oxide 79</p> <p>4.2.2 Nitrite 80</p> <p>4.2.3 Nitrosothiols (RSNOs) 81</p> <p>4.3 Basic Physicochemical Properties of H<sub>2</sub>S and Its Biological Relevant Metabolites 82</p> <p>4.3.1 H<sub>2</sub>S/HS− 83</p> <p>4.3.2 Polysulfides and Persulfide 85</p> <p>4.4 Inorganic Sulfur–Nitrogen Compounds 86</p> <p>4.4.1 HSNO/SNO− 87</p> <p>4.4.2 SSNO− 89</p> <p>4.4.3 SULFI/NO 90</p> <p>4.5 Putative Biological Relevance of the NO/H<sub>2</sub>S Chemical Interaction 90</p> <p>4.5.1 Pharmacological Activity 90</p> <p>4.5.2 Putative Sources of SSNO− and SULFI/NO <i>In Vivo </i>91</p> <p>4.5.3 Methods of Detection <i>In Vivo </i>92</p> <p>4.6 Summary and Conclusions 93</p> <p>Acknowledgment 93</p> <p>References 93</p> <p><b>5 H<sub>2</sub>S and Bioinorganic Metal Complexes </b><b>103<br /></b><i>Zachary J. Tonzetich</i></p> <p>List of Abbreviations 103</p> <p>5.1 Introduction 104</p> <p>5.2 Basic Ligative Properties of H<sub>2</sub>S/HS− 105</p> <p>5.3 H<sub>2</sub>S and Heme Iron 106</p> <p>5.4 H<sub>2</sub>S and Nonheme Iron 112</p> <p>5.5 H<sub>2</sub>S Chemistry with Other Metals 122</p> <p>5.6 H<sub>2</sub>S Sensing with Transition Metal Complexes 126</p> <p>5.7 Summary 131</p> <p>Acknowledgments 134</p> <p>References 134</p> <p><b>6 Measurement of Hydrogen Sulfide Metabolites Using the Monobromobimane Method </b><b>143<br /></b><i>Xinggui Shen, Ellen H. Speers, and Christopher G. Kevil</i></p> <p>List of Abbreviations 143</p> <p>6.1 Introduction 143</p> <p>6.1.1 Hydrogen Sulfide: Biological Significance 143</p> <p>6.1.2 Hydrogen Sulfide Chemistry 144</p> <p>6.1.3 Bioavailable Sulfide 144</p> <p>6.2 Monobromobimane: An Optimal Method of Bioavailable Sulfur Detection 145</p> <p>6.2.1 Monobromobimane Derivatization of Hydrogen Sulfide 146</p> <p>6.2.2 History of the Monobromobimane Method 147</p> <p>6.3 Procedures 148</p> <p>6.3.1 Sulfide-Dibimane Standard Synthesis 148</p> <p>6.3.2 Bioavailable Sulfide Preparation 149</p> <p>6.3.3 Monobromobimane Derivatization 149</p> <p>6.3.4 HPLC with Fluorescence Detection 150</p> <p>6.3.5 Mass Spectrometry Detection 150</p> <p>6.4 Caveats and Considerations 151</p> <p>Acknowledgment 152</p> <p>Disclosures 152</p> <p>References 152</p> <p><b>7 Fluorescent Probes for H<sub>2</sub>S Detection: Cyclization-Based Approaches </b><b>157<br /></b><i>Yingying Wang, Yannie Lam, Caitlin McCartney, Brock Brummett, Geat Ramush, and Ming Xian</i></p> <p>List of Abbreviations 157</p> <p>7.1 Introduction 157</p> <p>7.2 General Design of Nucleophilic Reaction-Cyclization Based Fluorescent Probes 159</p> <p>7.2.1 WSP Probes 159</p> <p>7.2.2 2,2′-Dithiosalicylic Ester-Based Probes 164</p> <p>7.2.3 Alkyl Halide-Based Probes 166</p> <p>7.2.4 Diselenide-Based Probes 167</p> <p>7.2.5 Selenenyl Sulfide-Based Probes 167</p> <p>7.2.6 Aldehyde Addition-Based Probes 169</p> <p>7.2.7 Michael Addition-Cyclization Based Probes 175</p> <p>7.3 Conclusions and Perspectives 177</p> <p>Acknowledgments 177</p> <p>References 177</p> <p><b>8 Fluorescent Probes for H<sub>2</sub>S Detection: Electrophile-Based Approaches </b><b>183<br /></b><i>Long Yi and Zhen Xi</i></p> <p>8.1 Introduction 183</p> <p>8.2 Selected Probes Based on Different Reaction Types 185</p> <p>8.2.1 Cleavage of C—O Bond 185</p> <p>8.2.2 Cleavage of C—S Bond 188</p> <p>8.2.3 Cleavage of C—Cl Bond 190</p> <p>8.2.4 Michael Addition 191</p> <p>8.2.5 Cleavage of C—N Bond 193</p> <p>8.2.6 Reduction of Aryl Azide 193</p> <p>8.3 Conclusion and Future Prospects 197</p> <p>References 199</p> <p><b>9 Fluorescent Probes for H<sub>2</sub>S Detection: Metal-Based Approaches </b><b>203<br /></b><i>Maria Strianese and Claudio Pellecchia</i></p> <p>9.1 Introduction 203</p> <p>9.2 Metal Displacement Approach 205</p> <p>9.2.1 Copper-Based Systems 205</p> <p>9.2.2 Zinc-Based Systems 214</p> <p>9.2.3 Different Metal-Based Systems 216</p> <p>9.3 Coordinative-Based Approach 218</p> <p>9.3.1 Metalloporphyrin-Based Systems 218</p> <p>9.3.1.1 Synthetic Systems 219</p> <p>9.3.1.2 Natural Systems 220</p> <p>9.3.2 Salen-Based Systems 220</p> <p>9.3.3 Systems with Different Organic Ligands 221</p> <p>9.4 H<sub>2</sub>S-Mediated Reduction of the Metal Center 223</p> <p>9.5 Conclusions and Future Outlooks 224</p> <p>References 225</p> <p><b>10 H<sub>2</sub>S Release from P=S and Se—S Motifs </b><b>235<br /></b><i>Rynne A. Hankins and John C. Lukesh III</i></p> <p>List of Abbreviations 235</p> <p>10.1 Introduction 235</p> <p>10.2 H<sub>2</sub>S Release from P=S Motifs 236</p> <p>10.2.1 GYY4137: Synthesis and Characterization of H<sub>2</sub>S Release 237</p> <p>10.2.2 GYY4137: Biological Studies 238</p> <p>10.2.3 GYY4137: Mechanistic Studies 240</p> <p>10.2.4 GYY4137: Structural Modifications and Activity of Analogs 242</p> <p>10.2.5 JK Donors: Cyclization-Assisted H<sub>2</sub>S Release from P=S Motifs 248</p> <p>10.3 H2S Release from Se—S Motifs 249</p> <p>10.3.1 Acyl Selenylsulfides: Synthesis and Characterization of H<sub>2</sub>S Release 251</p> <p>10.3.2 Acyl Selenylsulfides: Mechanistic Studies 251</p> <p>10.4 Acyl Selenylsulfides: Structural Modifications and Activity of Analogs 253</p> <p>10.5 Conclusions 253</p> <p>References 254</p> <p><b>11 Hydrogen Sulfide: The Hidden Player of Isothiocyanates Pharmacology </b><b>261<br /></b><i>Valentina Citi, Eugenia Piragine, Vincenzo Calderone, and Alma Martelli</i></p> <p>11.1 Organic Isothiocyanates as H<sub>2</sub>S-Donors 261</p> <p>11.2 Organic ITCs and Cardiovascular System 266</p> <p>11.2.1 Effect of ITCs as H<sub>2</sub>S Donors in Vascular Inflammation 266</p> <p>11.2.2 Vasorelaxing Effect of ITCs as H<sub>2</sub>S Donors 269</p> <p>11.2.3 Organic ITCs and Heart 270</p> <p>11.3 Chemopreventive Properties of ITCs 272</p> <p>11.4 Anti-nociceptive Effects of ITCs 274</p> <p>11.5 Anti-inflammatory and Antiviral Effects of ITCs 277</p> <p>11.6 Conclusion 280</p> <p>Acknowledgment 281</p> <p>References 281</p> <p><b>12 Persulfide Prodrugs </b><b>293<br /></b><i>Bingchen Yu, Zhengnan Yuan, and Binghe Wang</i></p> <p>List of Abbreviations 293</p> <p>12.1 Introduction 293</p> <p>12.2 Persulfide Prodrugs 295</p> <p>12.2.1 Structural Moieties That Have Been Studied for Their Ability to Cage and Release Persulfide Species 296</p> <p>12.2.2 Enzyme-Sensitive Prodrugs 298</p> <p>12.2.3 ROS-Sensitive Persulfide Prodrugs 303</p> <p>12.2.4 pH-Sensitive Persulfide Prodrugs 306</p> <p>12.2.5 Photo-Sensitive Persulfide Prodrugs 308</p> <p>12.2.6 H<sub>2</sub>S Prodrugs That Release H<sub>2</sub>S Via Persulfide Intermediate 309</p> <p>12.3 Challenges in Persulfide Prodrug Design and Potential Therapeutic Applications 310</p> <p>References 313</p> <p><b>13 COS-Based H<sub>2</sub>S Donors </b><b>321<br /></b><i>Annie K. Gilbert and Michael D. Pluth</i></p> <p>13.1 Introduction 321</p> <p>13.2 Properties of COS 322</p> <p>13.3 COS-Based H<sub>2</sub>S Delivery 323</p> <p>13.3.1 Stimuli Responsive COS/H<sub>2</sub>S Donors 325</p> <p>13.3.2 Bio-orthogonal Donor Activation 326</p> <p>13.3.3 Donors Activated by Nucleophiles 329</p> <p>13.3.4 Enzyme-Activated Donors 334</p> <p>13.3.5 pH-Activated Donors 337</p> <p>13.3.6 Fluorescent Donors 339</p> <p>13.4 Conclusions and Outlook 341</p> <p>Acknowledgments 342</p> <p>References 342</p> <p><b>14 Light-Activatable H<sub>2</sub>S Donors </b><b>347<br /></b><i>Petr Klán, Tomáš Slanina, and Peter Štacko</i></p> <p>14.1 Introduction 347</p> <p>14.2 Photophysical and Photochemical Concepts 347</p> <p>14.3 Phototherapeutic Window 349</p> <p>14.4 Light Sources 349</p> <p>14.5 (Photo)Physical Properties of H<sub>2</sub>S 351</p> <p>14.6 Mechanisms and Examples of H<sub>2</sub>S Photorelease 351</p> <p>14.6.1 Photorelease of H<sub>2</sub>S from Excited State 352</p> <p>14.6.2 Release of H<sub>2</sub>S from a Reactive Intermediate 355</p> <p>14.6.3 Photorelease of Potential H<sub>2</sub>S Donors 357</p> <p>14.6.4 Photosensitized H<sub>2</sub>S Release 362</p> <p>14.6.5 Photothermal Effect 364</p> <p>14.7 Outlook 365</p> <p>Acknowledgment 366</p> <p>References 366</p> <p><b>15 Macromolecular and Supramolecular Approaches for H<sub>2</sub>S Delivery </b><b>373<br /></b><i>Sarah N. Swilley-Sanchez, Zhao Li, and John B. Matson</i></p> <p>List of Abbreviations 373</p> <p>15.1 Introduction 375</p> <p>15.2 H<sub>2</sub>S-Donating Linear Polymers 377</p> <p>15.2.1 Pendant H<sub>2</sub>S Donors 378</p> <p>15.2.2 H<sub>2</sub>S Donors on Chain Ends 379</p> <p>15.2.3 Depolymerizable Polymers for the Release of H<sub>2</sub>S via COS 383</p> <p>15.3 H<sub>2</sub>S Delivery from Branched and Graft Polymer Topologies 384</p> <p>15.3.1 Graft Polymers for the Delivery of H<sub>2</sub>S 386</p> <p>15.4 Polymer Micelles for H<sub>2</sub>S Delivery 388</p> <p>15.4.1 H<sub>2</sub>S Donors Covalently Attached to Polymer Amphiphiles 389</p> <p>15.5 Polymer Networks for Localized H<sub>2</sub>S Delivery 394</p> <p>15.5.1 Physical Encapsulation of H<sub>2</sub>S Donors Within Networks 394</p> <p>15.5.2 Covalent Attachment of H<sub>2</sub>S Donors Within Hydrogels 396</p> <p>15.6 Other Polymeric Systems for the Encapsulation of H<sub>2</sub>S Donors 399</p> <p>15.6.1 Microfibers as H<sub>2</sub>S Donors 400</p> <p>15.6.2 Membranes as H<sub>2</sub>S Donors 400</p> <p>15.6.3 Microparticles and Nanoparticles as H<sub>2</sub>S Donors 401</p> <p>15.7 H<sub>2</sub>S Release via Supramolecular Systems 404</p> <p>15.7.1 Self-Assembled, Peptide-Based Materials for H<sub>2</sub>S Delivery 405</p> <p>15.7.2 Self-Assembled Nanoparticles and Proteins for H<sub>2</sub>S Delivery 410</p> <p>15.8 Conclusions and Future Perspectives 414</p> <p>References 416</p> <p><b>16 H2S and Hypertension </b><b>427<br /></b><i>Vincenzo Brancaleone, Mariarosaria Bucci, and Giuseppe Cirino</i></p> <p>List of Abbreviations 427</p> <p>16.1 Hypertension, Vascular Homeostasis and Mediators Controlling Blood Pressure 428</p> <p>16.2 Generation of H<sub>2</sub>S in the Cardiovascular System 429</p> <p>16.2.1 Biosynthetic Pathways 429</p> <p>16.2.2 Catabolic Pathway for H<sub>2</sub>S 430</p> <p>16.3 Relevance of H<sub>2</sub>S in Hypertension 432</p> <p>16.3.1 Preclinical Evidence 432</p> <p>16.3.2 Clinical Evidence 436</p> <p>16.4 Conclusions 437</p> <p>References 438</p> <p><b>17 H2S Supplementation and Augmentation: Approaches for Healthy Aging </b><b>445<br /></b><i>Christopher Hine, Jie Yang, Aili Zhang, Natalia Llarena, and Christopher Link</i></p> <p>List of Abbreviations 445</p> <p>17.1 Introduction and Background 445</p> <p>17.1.1 Global Aging Populations 445</p> <p>17.1.2 Pathophysiological Aspects of Aging 447</p> <p>17.1.3 Alterations in Sulfur Amino Acid Metabolism and Hydrogen Sulfide During Aging 448</p> <p>17.1.4 Geroscience Approaches to Address Longevity and Improved Healthspan, and Their Connection to Hydrogen Sulfide 451</p> <p>17.2 Hydrogen Sulfide Metabolism and Applications in Non-mammalian Aging 454</p> <p>17.2.1 Plants 454</p> <p>17.2.2 Bacteria 454</p> <p>17.2.3 Yeast 455</p> <p>17.2.4 Worms 458</p> <p>17.2.5 Flies 459</p> <p>17.3 Hydrogen Sulfide Metabolism and Applications in Nonhuman Mammalian Aging 460</p> <p>17.3.1 Standard Laboratory Rodents (Mice and Rats) 460</p> <p>17.3.2 Naked Mole-Rats 464</p> <p>17.4 Hydrogen Sulfide Metabolism and Applications in Human Aging and Aging-Related Disorders 464</p> <p>17.4.1 Human Exposure to H<sub>2</sub>S and Advances in Clinical Biomarker and Interventional H<sub>2</sub>S Approaches 464</p> <p>17.4.2 Cardiovascular Diseases 467</p> <p>17.4.3 Oncological Diseases 469</p> <p>17.5 Conclusions and Summary 472</p> <p>Acknowledgments 472</p> <p>References 472</p> <p><b>18 Aberrant Hydrogen Sulfide Signaling in Alzheimer’s Disease </b><b>489<br /></b><i>Bindu D. Paul</i></p> <p>List of Abbreviations 489</p> <p>18.1 Introduction 490</p> <p>18.1.1 Hydrogen Sulfide 490</p> <p>18.1.2 Protein Sulfhydration/Persulfidation 492</p> <p>18.1.3 Reciprocity of Protein Sulfhydration and Nitrosylation 492</p> <p>18.2 Alzheimer’s Disease 494</p> <p>18.2.1 Neuropathology of AD 494</p> <p>18.2.2 H<sub>2</sub>S Signaling in Alzheimer’s Disease 496</p> <p>18.2.3 Sulfhydration in Aging and AD 496</p> <p>18.3 Therapeutic Avenues 497</p> <p>Acknowledgments 499</p> <p>References 500</p> <p><b>19 Multifaceted Actions of Hydrogen Sulfide in the Kidney </b><b>507<br /></b><i>Balakuntalam S. Kasinath and Hak Joo Lee</i></p> <p>List of Abbreviations 507</p> <p>19.1 Introduction 508</p> <p>19.2 H<sub>2</sub>S Synthesis in the Kidney 509</p> <p>19.3 H<sub>2</sub>S and Kidney Physiology 511</p> <p>19.4 H<sub>2</sub>S and the Aging Kidney 513</p> <p>19.5 H<sub>2</sub>S and Acute Kidney Injury (AKI) 517</p> <p>19.5.1 H<sub>2</sub>S in AKI Due to Intrinsic Kidney Injury 517</p> <p>19.5.1.1 Ischemia-Induced AKI 517</p> <p>19.5.1.2 Rhabdomyolysis-Induced AKI 519</p> <p>19.5.1.3 Nephrotoxic AKI 519</p> <p>19.5.1.4 Glomerulonephritis-Associated AKI 520</p> <p>19.5.2 H<sub>2</sub>S in AKI Due to Obstruction of the Genitourinary Tract 521</p> <p>19.5.3 Injurious Role of H<sub>2</sub>S in AKI 521</p> <p>19.6 H<sub>2</sub>S in Chronic Kidney Disease (CKD) 521</p> <p>19.6.1 H<sub>2</sub>S in Obesity-Related CKD 524</p> <p>19.6.2 H<sub>2</sub>S in Diabetic Kidney Disease (DKD) 525</p> <p>19.6.3 H<sub>2</sub>S in Congestive Heart Failure (CHF) Associated CKD 530</p> <p>19.7 H<sub>2</sub>S and Preeclampsia 530</p> <p>19.8 H<sub>2</sub>S and Genitourinary Cancers 531</p> <p>19.9 Conclusion and Future Directions 531</p> <p>Acknowledgments 532</p> <p>References 532</p> <p>Index 551</p>
<p><b>MICHAEL D. PLUTH, PhD</b> is a Professor at the University of Oregon in the Department of Chemistry and Biochemistry. He is also a member of the Materials Science Institute, Knight Campus for Accelerating Scientific Impact, and Institute of Molecular Biology at the University of Oregon.
<p><b>Covers H<sub>2</sub>S interactions, methods of detection and delivery in biological environments, and a wide range of applications</b> <p>Research on hydrogen sulfide (H<sub>2</sub>S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H<sub>2</sub>S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H<sub>2</sub>S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities. <p><i>Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies</i> provides the foundation required for understanding the fundamental chemical biology of H<sub>2</sub>S while highlighting the compound’s therapeutic potential and medicinal applications. This book covers key aspects of H<sub>2</sub>S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H<sub>2</sub>S in biological environments; and the therapeutic and medicinal uses of exogenous H<sub>2</sub>S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field. <ul><li>Provides approaches for delivering H<sub>2</sub>S with relevance to biological and therapeutic applications</li> <li>Describes complex interactions of H<sub>2</sub>S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species </li> <li>Summarizes advances in available tools to detect, measure, and modulate H<sub>2</sub>S levels in biological environments, such as real-time methods for H<sub>2</sub>S fluorescence imaging in live cell and animal systems </li> <li>Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action </li> <li>Includes in-depth case studies of different systems in which H<sub>2</sub>S plays an important role</li></ul> <p><i>Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies</i> is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.