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<p>List of Contributors ix</p> <p>Preface to the Sixth Edition xvi</p> <p>1 Introduction: Two Centuries of Progress in Transfusion Medicine 1<br /><i>Walter H. (Sunny) Dzik and Michael F. Murphy</i></p> <p><b>Part I Basic Principles of Immunohaematology 11</b></p> <p>2 Essential Immunology for Transfusion Medicine 11<br /><i>Gregory A. Denomme</i></p> <p>3 Human Blood Group Systems 21<br /><i>Geoff Daniels and Sean Stowell</i></p> <p>4 Human Leukocyte Antigens 33<br /><i>H. Cliff Sullivan and Caroline R. Alquist</i></p> <p>5 Platelet and Neutrophil Antigens 47<br /><i>Brian R. Curtis</i></p> <p>6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 64<br /><i>Mark H. Yazer, Meghan Delaney and Gregory A. Denomme Copyrighted Material</i></p> <p><b>Part II Complications of Transfusions 77</b></p> <p>7 Investigation of Acute Transfusion Reactions 77<br /><i>Heather Leary, Kathryn E. Webert and Nancy M. Heddle</i></p> <p>8 Haemolytic Transfusion Reactions 91<br /><i>Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman</i></p> <p>9 Febrile and Allergic Transfusion Reactions 108<br /><i>Sarah K. Harm and Mark K. Fung</i></p> <p>10 Transfusion- Associated Circulatory Overload 120<br /><i>Robert B. Klanderman and Alexander P.J. Vlaar</i></p> <p>11 Transfusion- Related Acute Lung Injury (TRALI) 130<br /><i>Alexander P.J. Vlaar and Rick Kapur</i></p> <p>12 Purported Adverse Effects of ‘Old Blood’ 145<br /><i>Lirong Qu and Darrell J. Triulzi</i></p> <p>13 Transfusion- Induced Immunomodulation 154<br /><i>Neil Blumberg, Majed A. Refaai and Joanna M. Heal</i></p> <p>14 Transfusion- Associated Graft- versus- Host Disease and Microchimerism 166<br /><i>Alexandra Budhai, Richard O. Francis and Beth H. Shaz</i></p> <p>15 Posttransfusion Purpura 181<br /><i>Michael F. Murphy</i></p> <p>16 Heparin- Induced Thrombocytopenia 187<br /><i>Theodore E. Warkentin and Andreas Greinacher</i></p> <p>17 Transfusion- Transmitted Infections 206<br /><i>Steven J. Drews and Roger Y. Dodd</i></p> <p>18 Bacterial Contamination 221<br /><i>Sandra Ramírez- Arcos and Mindy Goldman</i></p> <p>19 Emerging Infections and Transfusion Safety 229<br /><i>Roger Y. Dodd</i></p> <p><b>Part III Practice in Blood Centres and Hospitals 238</b></p> <p>20 Regulatory Aspects of Blood Transfusion 238<br /><i>Louis M. Katz, Peter Flanagan and William G. Murphy</i></p> <p>21 The Role of Hemovigilance in Transfusion Safety 247<br /><i>Katharine A. Downes and Barbee I. Whitaker</i></p> <p>22 Donors and Blood Collection 257<br /><i>Marc Germain and Pierre Tiberghien</i></p> <p>23 Blood Donation Testing and the Safety of the Blood Supply 269<br /><i>Mindy Goldman and Steven J. Drews</i></p> <p>24 Production and Storage of Blood Components 278<br /><i>Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo</i></p> <p>25 Blood Transfusion in Hospitals 290<br /><i>Zoe K. McQuilten, Erica M. Wood, Mark H. Yazer and Michael F. Murphy</i></p> <p>26 Disaster Preparedness 313<br /><i>Heidi Doughty, Fateha Chowdhury and Richard Rackham</i></p> <p>27 Blood Transfusion in a Global Context 324<br /><i>David J. Roberts, Imelda Bates, Stephen P. Field, Aggrey Dhabangi, Jean Pierre Allain and Meghan Delaney</i></p> <p><b>Part IV Clinical Transfusion Practice 337</b></p> <p>28 Inherited and Acquired Disorders of Haemostasis 337<br /><i>Irina Chibisov, Jansen Seheult and Franklin Bontempo</i></p> <p>29 Point- of- Care Haemostasis Testing 353<br /><i>Katrina M. Morgan, Matthew D. Neal, Louis Alarcon and Christine M. Leeper</i></p> <p>30 Transfusion in Bleeding Patients 365<br /><i>Aaron S. Hess, Lynn G. Stansbury and John R. Hess</i></p> <p>31 Transfusion in Non- Bleeding Medical and Surgical Patients 374<br /><i>Killian Donovan, Akshay Shah, Stuart McKechnie and Simon J. Stanworth</i></p> <p>32 Transfusion in Malignant Haematological Disease 385<br /><i>Lise J. Estcourt and Michael F. Murphy</i></p> <p>33 Transfusion in Benign Haematological Disease 399<br /><i>Eric Salazar and Christopher A. Tormey</i></p> <p>34 Transfusion in Patients with Haemoglobinopathies 409<br /><i>Yvette C. Tanhehco and Patricia A. Shi</i></p> <p>35 Transfusing Neonates and Infants 417<br /><i>Marianne E. Yee and Cassandra D. Josephson</i></p> <p>36 Immunodeficiency and Immunoglobulin Therapy 426<br /><i>Siraj A. Misbah</i></p> <p><b>Part V Patient Blood Management 441</b></p> <p>37 Development of a Patient Blood Management Programme 441<br /><i>Jonathan H. Waters</i></p> <p>38 Perioperative Patient Blood Management 451<br /><i>Martin Shao Foong Chong, Martin Rooms, Ravishankar Rao Baikady and Toby Richards</i></p> <p>39 Restrictive Transfusion Practice and How to Implement It 465<br /><i>Marie A. Hollenhorst and Lawrence Tim Goodnough</i></p> <p>40 Using Data to Support Patient Blood Management 476<br /><i>Nadia B. Hensley, Sandaruwani Abeysiri and Steven M. Frank</i></p> <p><b>Part VI Cellular Therapy and Transplantation 489</b></p> <p>41 Regulation and Accreditation in Cellular Therapy 489<br /><i>Julia Wolf, Zbigniew (Ziggy) M. Szczepiorkowski and James Griffin</i></p> <p>42 Stem Cell Collection and Therapeutic Apheresis 504<br /><i>Khaled El- Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski</i></p> <p>43 Haemopoietic Stem Cell Processing and Storage 519<br /><i>Akash Gupta and Ronan Foley</i></p> <p>44 Haematopoietic Cell Transplantation 531<br /><i>Richard Salisbury, Yisu Gu, Rachael Hough and Robert D. Danby</i></p> <p>45 CAR- T Cells and Recent Advances in Clinical Cellular Immunotherapy 543<br /><i>Yisu Gu, Alex Rampotas, Connor Sweeney, David J. Roberts and Ronjon Chakraverty</i></p> <p>46 Tissue Banking 554<br /><i>Akila Chandrasekar, Richard Lomas and Paul Rooney</i></p> <p><b>Part VII Development of the Evidence Base for Transfusion 561</b></p> <p>47 Observational and Interventional Trials in Transfusion Medicine 561<br /><i>Alan T. Tinmouth, Dean Fergusson and Paul C. Hébert</i></p> <p>48 Getting the Most Out of the Evidence for Transfusion Medicine and Lessons from the COVID- 19 Pandemic 576<br /><i>Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Yulia Lin</i></p> <p>49 A Primer on Biostatistics 590<br /><i>Andrew W. Shih, Na Li, Celina Montemayor and Nancy M. Heddle</i></p> <p>50 A Primer on Health Economics 609<br /><i>Seema Kacker and Aaron A. R. Tobian</i></p> <p>51 Scanning the Future of Transfusion Medicine 620<br /><i>Jay E. Menitove, Paul M. Ness, Suzanne R. Thibodeaux and Edward L. Snyder</i></p> <p>Index 632</p>

<P><B>About the Editors</b></P> <P><B>Michael F. Murphy, MD, FRCP, FRCPath, FFPath,</B> is Professor of Blood Transfusion Medicine at the University of Oxford, and Consultant Haematologist for NHS Blood and Transplant and the Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. <P><B>David J. Roberts, MB, ChB, DPhil, FRCPath,</B> is Professor of Haematology at the University of Oxford, Medical Director for Pathology for NHS Blood and Transplant and also works as a Consultant Haematologist in the Department of Haematology, John Radcliffe Hospital, Oxford, UK. <P><B>Mark H. Yazer, MD</B> is Professor of Pathology at the University of Pittsburgh, an Adjunct Professor of Clinical Immunology at the University of Southern Denmark, Odense, Denmark, and a Visiting Professor of Pathology at Tel Aviv University. His research interest is in blood use in massive bleeding. <P><B>Nancy M. Dunbar, MD</B> is Associate Professor of Pathology and Laboratory Medicine at the Geisel School of Medicine at Dartmouth and serves as the Medical Director of the Blood Bank at Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

<p><b>Practical Transfusion Medicine, Sixth Edition</b></p> <p>The pace of change in transfusion medicine is relentless, with new scientific and technological developments and continuing efforts to improve transfusion practice. This sixth edition of <i>Practical Transfusion Medicine</i> has been updated significantly to reflect the rapid changes in transfusion medicine since the fifth edition was published in 2017. <p>The primary purpose of this edition remains the same as the first: to provide a comprehensive guide to transfusion medicine. This book contains more depth of information than standard handbooks on transfusion medicine, whilst being more concise and approachable than a standard reference text. <P>This book covers the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals and clinical transfusion practice. This sixth edition includes a new section on patient blood management, cellular and tissue therapy, organ transplantation and the development of the evidence base for transfusion. It also features a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding. <P>This sixth edition of <I>Practical Transfusion Medicine </I>provides accessible and comprehensive coverage of the field of transfusion medicine. It is a standalone text that will be useful to clinical and scientific staff: not only for trainees who require an overview of the field, but also for established practitioners who are involved in some aspect of transfusion medicine and require a comprehensive, accessible reference book.

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