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<p>Preface ix</p> <p>List of Contributors xi</p> <p><b>Part 1 Concerns in Pregnancy</b></p> <p>1 Alcohol Use in Pregnancy and Lactation 3<br /><i>Ruta M. Nonacs</i></p> <p>2 Smoking, Vaping, and Nicotine Exposure 9<br /><i>John Byrne and George Saade</i></p> <p>3 Opioid Use, Misuse, and Addiction in Pregnancy and Postpartum 15<br /><i>Mishka Terplan</i></p> <p>4 Depression 21<br /><i>Kimberly Yonkers</i></p> <p><b>Part 2 Antenatal Testing</b></p> <p>5 Prenatal Testing for Chromosomal Abnormalities 29<br /><i>Mary E. Norton</i></p> <p>6 Fetal Echocardiography 41<br /><i>Joshua A. Copel</i></p> <p>7 Clinical Use of Doppler 49<br /><i>Henry L. Galan</i></p> <p>8 Antepartum Testing 61<br /><i>Michael P. Nageotte</i></p> <p>9 Fetal Blood Sampling and Transfusion 69<br /><i>Patricia Santiago‐Munoz</i></p> <p>10 Preconception Genetic Screening 77<br /><i>Lauren Sayres and Jeffrey A. Kuller</i></p> <p><b>Part 3 Maternal Disease</b></p> <p>11 Maternal Anemia 89<br /><i>Elaine Duryea</i></p> <p>12 Hemoglobinopathies in Pregnancy 97<br /><i>Bradley Sipe and Judette Louis</i></p> <p>13 Fetal and Neonatal Alloimmune Thrombocytopenia 105<br /><i>Russell Miller and Richard Berkowitz</i></p> <p>14 Rheumatological Disorders 113<br /><i>Lisa R. Sammaritano and Bonnie L. Bermas</i></p> <p>15 Antiphospholipid Syndrome 125<br /><i>Robert M. Silver</i></p> <p>16 Inherited Thrombophilias 131<br /><i>Andra H. James and Jerome J. Federspiel</i></p> <p>17 Valvular Heart Disease in Pregnancy 141<br /><i>Blake Zwerling and Afshan B. Hameed</i></p> <p>18 Peripartum Cardiomyopathy 165<br /><i>Sarah Rae Easter and Carolyn M. Zelop</i></p> <p>19 Thromboembolism 181<br /><i>Michael J. Paidas</i></p> <p>20 Renal Disease 201<br /><i>Shivani Patel</i></p> <p>21 Obesity 209<br /><i>Patrick S. Ramsey</i></p> <p>22 Diabetes Mellitus 219<br /><i>Mark B. Landon and Steven G. Gabbe</i></p> <p>23 Thyroid Disorders 231<br /><i>Elizabeth O. Buschur and Stephen F. Thung</i></p> <p>24 Hepatitis in Pregnancy 241<br /><i>Andrew Myers, Asa Oxner, John Sinnott, and Christian Brechot</i></p> <p>25 Asthma 253<br /><i>Michael Schatz</i></p> <p>26 Epilepsy 263<br /><i>Thomas McElrath</i></p> <p>27 Chronic Hypertension 273<br /><i>Michal Fishel Bartal and Baha M. Sibai</i></p> <p>28 Cytomegalovirus, Genital Herpes, Rubella, and Toxoplasmosis 285<br /><i>Kerry E. Drury and Brenna L. Hughes</i></p> <p>29 Syphilis 293<br /><i>Emily H. Adhikari</i></p> <p>30 Vector‐Borne Diseases in Pregnancy: Zika, West Nile, and Chagas Disease 301<br /><i>Karin Nielsen‐Saines and Tara Kerin</i></p> <p>31 Influenza 317<br /><i>Amanda C. Zofkie and Vanessa Rogers</i></p> <p>32 Malaria 323<br /><i>Blair J. Wylie</i></p> <p>33 Human Immunodeficiency Virus Infection 333<br /><i>Emily H. Adhikari</i></p> <p>34 Parvovirus B19 343<br /><i>Kathy C. Matthews, Emilie L. Vander Haar, and Laura E. Riley</i></p> <p>35 Group B Streptococcus 351<br /><i>Caitlin A. MacGregor, and Mara J. Dinsmoor</i></p> <p>36 Biliary, Liver, and Pancreatic Disease 361<br /><i>Vic Velanovich, Elizabeth Hoover, and Stephanie Ros</i></p> <p><b>Part 4 Obstetric Problems</b></p> <p>37 Cervical Insufficiency 375<br /><i>Rupsa C. Boelig and Vincenzo Berghella</i></p> <p>38 Nausea and Vomiting 387<br /><i>Jared T. Roeckner and Haywood L. Brown</i></p> <p>39 Fetal Death and Stillbirth 397<br /><i>Alexander M. Saucedo and Robert M. Silver</i></p> <p>40 Abnormal Amniotic Fluid Volume 407<br /><i>Christina M. Ackerman, Thomas R. Moore, and Heather S. Lipkind</i></p> <p>41 Fetal Growth Restriction 421<br /><i>Jodi S. Dashe and Anne M. Ambia</i></p> <p>42 Rh and Other Blood Group Alloimmunizations 431<br /><i>Kenneth J. Moise Jr</i></p> <p>43 Preterm Labor 443<br /><i>Hyagriv N. Simhan</i></p> <p>44 Prevention of Preterm Birth 449<br /><i>Anna King and Sarah J.E. Stock</i></p> <p>45 Premature Rupture of the Membranes 461<br /><i>Brian M. Mercer</i></p> <p>46 Indicated Late‐Preterm and Early‐Term Deliveries 475<br /><i>Catherine Y. Spong</i></p> <p>47 Chorioamnionitis 481<br /><i>Catalin S. Buhimschi and Irina A. Buhimschi</i></p> <p>48 Third‐Trimester Bleeding 493<br /><i>Ilina D. Pluym and Christina S. Han</i></p> <p>49 Amniotic Fluid Embolism 507<br /><i>Irene A. Stafford and Michael A. Belfort</i></p> <p>50 Preeclampsia 517<br /><i>Michal Fishel Bartal and Baha M. Sibai</i></p> <p><b>Part 5 Labor and Delivery</b></p> <p>51 Elective Induction of Labor 531<br /><i>Rachel G. Sinkey</i></p> <p>52 Electronic Fetal Heart Rate Monitoring 539<br /><i>David A. Miller</i></p> <p>53 Breech Delivery 555<br /><i>G. Justus Hofmeyr, and Mercy‐Nkuba Nassali</i></p> <p>54 Vaginal Birth After Cesarean 563<br /><i>James R. Scott</i></p> <p>55 Placenta Accreta Spectrum 571<br /><i>Robert M. Silver and Deirdre J. Lyell</i></p> <p>56 Shoulder Dystocia 581<br /><i>George A. Macones and Robert B. Gherman</i></p> <p>57 Twins, Triplets, and Beyond 587<br /><i>Mary E. D’Alton</i></p> <p>58 Postpartum Hemorrhage 601<br /><i>David B. Nelson</i></p> <p>Appendix A: Evaluation of Fetal Health and Defects 613<br /><i>Lynn L. Simpson</i></p> <p>Index 629</p>

<p><b>About the Editors</b> <p><b>JOHN T. QUEENAN</b>, MD, Professor and Chairman Emeritus, Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC, USA. <p><b>CATHERINE Y. SPONG</b>, MD, is a Professor and Vice Chair in the Department of Obstetrics and Gynecology at University of Texas Southwestern Medical Center, Dallas, TX, USA. She also serves as Chief of the Department's Division of Maternal-Fetal Medicine. <p><b>CHARLES J. LOCKWOOD</b>, MD, MHCM, is Senior Vice President of USF Health, Dean of Morsani College of Medicine and a Professor of Obstetrics and Gynecology, and Public Health at the University of South Florida in Tampa, FL, USA.

<p><b>Protocols for High-Risk Pregnancies: An Evidence-Based Approach, 7th edition</b> <p>Through seven editions, <i>Protocols for High-Risk Pregnancies</i> has helped busy obstetricians keep pace with a constantly evolving field. Providing just-in-time content, its focus on protocols and guidelines helps organize medical thinking, avoid heuristic errors of omission and commission, and optimize maternal and fetal outcomes. <p>As with the prior six editions, the editors have once again assembled some of the world's top obstetrical and medical experts. This seventh edition has also been expanded to include a number of new topics, including: <ul> <li>Protocols on opioid use, misuse and addition in pregnancy and postpartum</li> <li>Noninvasive prenatal diagnosis of aneuploidy</li> <li>Periconceptual genetic screening</li> <li>Expanded protocols on maternal valvular heart disease and cardiomyopathies</li> <li>Protocols on arboviruses, including Zika and malaria</li> </ul> <p><i>Protocols for High-Risk Pregnancies: An Evidence-Based Approach</i> will be an essential reference for obstetricians, medical students, general practitioners and all medical professionals who are seeking the most up-to-date information and guidance on high-risk pregnancies.

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