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<p>Foreword</p> <p>Preface</p> <p>List of Contributors</p> <p>About the Editors</p> <p>Abbreviations</p> <p>PART I: INTRODUCTION TO RADIOPHARMACEUTICALS</p> <p>1. Targeted Diagnostic Radiopharmaceuticals: Design Options for Small Molecule Radiotracers</p> <p>Michael R. Kilbourn</p> <p>2. Concepts and Issues for Therapeutic Radiopharmaceuticals</p> <p>Alexandra R. Sowa Dumond and Peter J. H. Scott</p> <p>PART II: PRODUCTION OF RADIONUCLIDES</p> <p>3. Production of Short Half-life PET Radionuclides</p> <p>Michael R. Kilbourn, Melissa E. Rodnick and Mara Clark</p> <p>4. Production of Radionuclides used in SPECT</p> <p>Salma Jivan and Thomas J. Ruth</p> <p>5. Production of Therapeutic Radionuclides</p> <p>C. Shaun Loveless and Suzanne E. Lapi</p> <p>PART III: SYNTHETIC METHODS FOR RADIOPHARMACEUTICALS</p> <p>6. Synthesis of 13N- and 15O-labeled Radiopharmaceuticals</p> <p>Krishna R. Pulagam, Vanessa Gómez-Vallejo, Fernando López-Gallego, Luka Rejc and Jordi Llop</p> <p>7. Radiochemistry with Carbon-11</p> <p>Stephen Thompson, Steven Kealey, Selena M. Sephton and Franklin I. Aigbirhio</p> <p>8. Fluorine-18 Radiochemistry</p> <p>Allen F. Brooks, Katarina J. Makaravage, Jay Wright, Melanie S. Sanford and Peter J. H. Scott</p> <p>9. Synthesis of 68Ga-labeled Radiopharmaceuticals</p> <p>Benjamin P. Burke and Stephen J. Archibald </p> <p>10. Cu-Mediated Radiohalogenation of Organoboranes</p> <p>Sean W. Reilly and Robert H. Mach</p> <p>11. The radiochemistry of zirconium</p> <p>Jason P. Holland</p> <p>12. 99mTc Radiopharmaceutical Chemistry</p> <p>Dionysia Papagiannopoulou</p> <p>PART IV: PRACTICAL ASPECTS OF RADIOPHARMACEUTICAL PRODUCTION AND USE</p> <p>13. Automated Synthesis Modules for PET Radiochemistry</p> <p>Laura Bruton and Peter J. H. Scott</p> <p>14. Automation of PET Radiopharmaceutical Quality Control</p> <p>Arkadij Elizarov</p> <p>15. Moving PET Drugs from the Lab to the Patient in USA</p> <p>David W. Dick</p> <p>16. Moving from the Lab to the Patient in Asia</p> <p>Dae Yoon Chi</p> <p>17.      Moving a radiotracer form bench to bedside in Europe</p> <p>Koen Vermeulen, Alfons Verbruggen, Guy Bormans and Frederik Cleeren</p> <p>PART V: MAJOR APPLICATIONS OF RADIOPHARMACEUTICALS</p> <p>18. Radiopharmaceuticals in Oncology</p> <p>Jeroen A.C.M. Goos, Outi Keinänen, Brian M. Zeglis and Jason S. Lewis</p> <p>19. Neurological applications of Radiopharmaceuticals</p> <p>Mehdi Djekidel and Nicolaas I. Bohnen</p> <p>20. Cardiac Applications of Radiopharmaceuticals</p> <p>John P. Bois and Robert J. Gropler</p> <p>21. Radiopharmaceuticals in Pediatric Nuclear Medicine</p> <p>Scott E. Snyder, Elizabeth R. Butch and Barry L. Shulkin</p> <p>22. PET Imaging in Drug Discovery and Development</p> <p>David J. Donnelly</p> <p>INDEX</p>

<p><b>Edited by</b> <p><b>Michael R. Kilbourn, PhD,</b> is Professor Emeritus, Radiology, at the University of Michigan. He retired after 25 years of directing and expanding the University's PET Cyclotron and Radiochemistry program. Professor Kilbourn is the author of over 200 peer-reviewed scientific papers and 31 book chapters, and is the 2009 recipient of the Paul C. Aebersold Award for Outstanding Achievements in Basic Science Applied to Nuclear Medicine. <p><b>Peter J. H. Scott, PhD,</b> is Associate Professor, Radiology, and Director of the PET Center at the University of Michigan. His research focuses on developing new methods for radiolabeling bioactive molecules and the design and synthesis of new radiotracers for PET imaging. Professor Scott has published over 100 papers, 170 abstracts, and 30 book chapters, edited 4 books, and is listed as an inventor on multiple patents. In 2019 he received a Distinguished Investigator Award from the Academy for Radiology & Biomedical Imaging Research.

<p><b>The thoroughly updated new edition of the authoritative reference in Radiopharmaceutical Sciences</b> <p>The second edition of <i>Handbook of Radiopharmaceuticals</i> is a comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provide readers with an immersive examination of radiochemistry, nuclear medicine, molecular imaging, and more. <p>Since the first edition of the <i>Handbook</i> was published, Nuclear Medicine and Radiopharmaceutical Sciences have undergone major changes. New radiopharmaceuticals for diagnosis and therapy have been approved by the FDA, the number of clinical PET and SPECT scans have increased significantly, and advances in Artificial Intelligence have dramatically improved research techniques. This fully revised edition reflects the current state of the field and features substantially updated and expanded content. New chapters cover topics including current Good Manufacturing Practice (cGMP), regulatory oversight, novel approaches to quality control—ensuring that readers are informed of the exciting developments of recent years. This important resource: <ul> <li>Features extensive new and revised content throughout</li> <li>Covers key areas of application for diagnosis and therapy in oncology, neurology, and cardiology</li> <li>Emphasizes the multidisciplinary nature of Radiopharmaceutical Sciences</li> <li>Discusses how drug companies are using modern radiopharmaceutical imaging techniques to support drug discovery</li> <li>Examines current and emerging applications of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT)</li> </ul> <p>Edited by recognized experts in radiochemistry and PET imaging, <i>Handbook of Radiopharmaceuticals: Radiochemistry and Applications^,2nd Edition</i> is an indispensable reference for post-doctoral fellows, research scientists, and professionals in the pharmaceutical industry, and for academics, graduate students, and newcomers in the field of radiopharmaceuticals.

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