Details

<p>Dedication v</p> <p>Contributors xv</p> <p>Preface xxv</p> <p>Acknowledgments xxvii</p> <p><b>Section I Hemolymphatic Tissue 1</b></p> <p>Chapter 1 Embryonic and Fetal Hematopoiesis 3<br /><i>Kelli L. Boyd and Brad Bolon</i></p> <p>Chapter 2 Stem Cell Biology 9<br /><i>Dori L. Borjesson and Jed A. Overmann</i></p> <p>Chapter 3 Structure of the Bone Marrow 18<br /><i>Nicole I. Stacy and John W. Harvey</i></p> <p>Chapter 4 The Hematopoietic System 27<br /><i>Bruce D. Car and Davis M. Seelig</i></p> <p>Chapter 5 Vasculogenesis and Endothelial Cell Production 37<br /><i>Jong Hyuk Kim</i></p> <p>Chapter 6 Cluster of Differentiation (CD) Antigens 41<br /><i>Melinda J. Wilkerson and Nora L. Springer</i></p> <p>Chapter 7 Major Histocompatibility Complex Antigens 48<br /><i>Paul R. Hess</i></p> <p>Chapter 8 Lymphocyte Biology and Functions 63<br /><i>Ian Tizard</i></p> <p>Chapter 9 Structure and Function of Primary and Secondary Lymphoid Tissue 74<br /><i>Cleverson D. Souza, Meredeth Mcentire, V.E. Ted Valli, and Robert M. Jacobs</i></p> <p><b>Section II Hematotoxicity 85</b></p> <p>Chapter 10 Design and Methods of Nonclinical Hematotoxicity Studies 87<br /><i>William J. Reagan and Armando R. Irizarry Rovira</i></p> <p>Chapter 11 Interpretation of Hematologic Data in Nonclinical Studies 93<br /><i>JEFFREY Mccartney</i></p> <p>Chapter 12 Nonclinical Evaluation of Compound-Related Cytopenias 100<br /><i>Laurie G. O’rourke</i></p> <p>Chapter 13 Nonclinical Evaluation of Compound‐Related Alterations in Hemostasis 108<br /><i>F. Poitout‐Belissent</i></p> <p>Chapter 14 Preclinical Evaluation of Immunotoxicity 116<br /><i>Kristin L. Henson</i></p> <p>Chapter 15 Blood and Bone Marrow Toxicity Induced by Drugs, Heavy Metals, Chemicals , and Toxic Plants 122<br /><i>Douglas J. Weiss</i></p> <p>Chapter 16 Acute Myelotoxicity and Myelitis in Domestic and Laboratory Animals 133<br /><i>Adam D. Aulbach and Douglas J. Weiss</i></p> <p>Chapter 17 Chronic Inflammation and Secondary Myelofibrosis in Domestic and Laboratory Animals 138<br /><i>Adam D. Aulbach and Douglas J. Weiss</i></p> <p>Chapter 18 Infectious Injury to Bone Marrow 144<br /><i>K. Jane Wardrop</i></p> <p><b>Section III Erythrocytes 149</b></p> <p>Chapter 19 Erythropoiesis 151<br /><i>Christine Swardson Olver</i></p> <p>Chapter 20 Erythrocyte Structure and Function 158<br /><i>Christine Swardson Olver</i></p> <p>Chapter 21 Erythrocyte Biochemistry 166<br /><i>John W. Harvey</i></p> <p>Chapter 22 Erythrokinetics and Erythrocyte Destruction 172<br /><i>Andrea Pires Dos Santos, and John A. Christian</i></p> <p>Chapter 23 Reticulocyte and Heinz Body Staining and Enumeration 181<br /><i>Harold Tvedten and Andreas Moritz</i></p> <p>Chapter 24 Erythrocyte Morphology 188<br /><i>Anne M. Barger</i></p> <p>Chapter 25 Classification and Laboratory Evaluation of Anemia 198<br /><i>Harold Tvedten</i></p> <p>Chapter 26 Erythrocytosis 209<br /><i>John F. Randolph, Mark E. Peterson, and Erica Behling-Kelly</i></p> <p>Chapter 27 Iron and Copper Deficiencies, and Disorders of Iron Metabolism 215<br /><i>Lauren B. Radakovich and Christine Swardson Olver</i></p> <p>Chapter 28 The Porphyrias—Disorders of Defective Heme Synthesis 221<br /><i>Andrea A. Bohn</i></p> <p>Chapter 29 Hereditary Erythroenzymopathies 229<br /><i>Urs Giger</i></p> <p>Chapter 30 Erythrocyte Membrane Defects 238<br /><i>Mutsumi Inaba and Joanne B. Messick</i></p> <p>Chapter 31 Congenital Dyserythropoiesis 248<br /><i>Douglas J. Weiss</i></p> <p>Chapter 32 Anemia Associated with Oxidative Injury 252<br /><i>Erica Behling-Kelly and Ashleigh Newman</i></p> <p>Chapter 33 Anemia Caused by Rickettsia, Mycoplasma, and Protozoa 260<br /><i>Susan Fielder, Robin W. Allison, and James H. Meinkoth</i></p> <p>Chapter 34 Anemia Associated with Bacterial and Viral Infections 273<br /><i>George M. Barrington and Debra C. Sellon</i></p> <p>Chapter 35 Immune-Mediated Anemia in the Dog 278<br /><i>Jillian M. Haines, Andrew Mackin, and Michael J. Day</i></p> <p>Chapter 36 Immune-Mediated Anemia in the Cat 292<br /><i>Ashleigh Newman and Tracy Stokol</i></p> <p>Chapter 37 Immune-Mediated Anemia in Ruminants and Horses 300<br /><i>Jenifer R. Gold</i></p> <p>Chapter 38 Precursor-Targeted Immune-Mediated Anemia and Pure Red Cell Aplasia in Dogs and Cats 307<br /><i>Cynthia A. Lucidi</i></p> <p>Chapter 39 Anemia of Inflammatory, Neoplastic, Renal, and Endocrine Diseases 313<br /><i>Agata K. Grzelak and Michael M. Fry</i></p> <p>Chapter 40 Aplastic Anemia 318<br /><i>Jennifer L. Brazzell and Douglas J. Weiss</i></p> <p><b>Section IV Leukocytes 323</b></p> <p>Chapter 41 Granulopoiesis 325<br /><i>M. Judith Radin and Maxey L. Wellman</i></p> <p>Chapter 42 Neutrophil Structure and Biochemistry 333<br /><i>Claire B. Andreasen</i></p> <p>Chapter 43 Neutrophil Function and Response 339<br /><i>Dana N. Levine and Claire B. Andreasen</i></p> <p>Chapter 44 Neutrophil Function Disorders 347<br /><i>Stefano Comazzi, Luca Aresu, and Douglas J. Weiss</i></p> <p>Chapter 45 Clinical Evaluation of Neutrophil Function 354<br /><i>Stefano Comazzi</i></p> <p>Chapter 46 Eosinophils and Their Disorders 363<br /><i>Karen M. Young and Elizabeth A. Layne</i></p> <p>Chapter 47 Basophils, Mast Cells, and Their Disorders 373<br /><i>Brandy C. Kastl and Lisa M. Pohlman</i></p> <p>Chapter 48 Monocytes, Macrophages, and Dendritic Cell Production 381<br /><i>Cleverson D. Souza and Douglas J. Weiss</i></p> <p>Chapter 49 Monocytes and Macrophages and Their Disorders 386<br /><i>Cleverson D. Souza and Meaghan V. Eren</i></p> <p>Chapter 50 Lymphocyte Ontogeny and Lymphopoiesis 395<br /><i>Amy L. Warren and Robin M. Yates</i></p> <p>Chapter 51 Structure, Function, and Disorders of Lymphoid Tissue 402<br /><i>Amy L. Warren and Robin M. Yates</i></p> <p>Chapter 52 Systemic Lupus Erythematosus 414<br /><i>Luc Chabanne</i></p> <p>Chapter 53 Feline Immunodeficiency Virus 424<br /><i>Margaret J. Hosie and Hans Lutz</i></p> <p>Chapter 54 T Cell, Immunoglobulin, and Complement Immunodeficiency Disorders 431<br /><i>Peter J. Felsburg</i></p> <p>Chapter 55 Severe Combined Immunodeficiencies 436<br /><i>Steven E. Suter</i></p> <p>Chapter 56 Lymphadenopathy Not Caused by Lymphoma 442<br /><i>Harold Tvedten</i></p> <p><b>Section V Hematologic Neoplasia 449</b></p> <p>Chapter 57 Cell-Cycle Control in Hematopoietic Cells 451<br /><i>Jaime F. Modiano and Catherine A. St. Hill</i></p> <p>Chapter 58 Epidemiology of Hematopoietic Neoplasia 457<br /><i>Michelle G. Ritt</i></p> <p>Chapter 59 Genetics of Hematopoietic Neoplasia 463<br /><i>Diana Giannuzzi, Jaime F. Modiano, and Matthew Breen</i></p> <p>Chapter 60 Transforming Retroviruses 471<br /><i>Mary Jo Burkhard</i></p> <p>Chapter 61 Cytochemical Staining and Immunocytochemistry 478<br /><i>Rose E. Raskin, Kelly Santangelo, and Klaudia Polak</i></p> <p>Chapter 62 Determination of Clonality 500<br /><i>Yuko Goto-Koshino and Hajime Tsujimoto</i></p> <p>Chapter 63 Immunophenotyping 508<br /><i>Austin K. Viall</i></p> <p>Chapter 64 Flow Cytometry in Hematologic Neoplasia 515<br /><i>Jaime L. Tarigo, Davis M. Seelig, and Anne C. Avery</i></p> <p>Chapter 65 Classification and General Features of Lymphoma and Leukemia 528<br /><i>Barbara C. Rutgen and Jennifer Bouschor</i></p> <p>Chapter 66 Myeloproliferative Neoplasms 538<br /><i>Eric J. Fish</i></p> <p>Chapter 67 Myelodysplastic Syndromes 548<br /><i>Douglas J. Weiss and Rance K. Sellon</i></p> <p>Chapter 68 Acute Myeloid Leukemia 557<br /><i>Tracy Stokol</i></p> <p>Chapter 69 B‐Cell Tumors 570<br /><i>Luca Aresu, Stefano Comazzi, Laura Marconato, and Francesco Bertoni</i></p> <p>Chapter 70 Plasma Cell Tumors 588<br /><i>Antonella Borgatti</i></p> <p>Chapter 71 Hodgkin and Hodgkin‐Like Lymphoma 599<br /><i>Daniel A. Heinrich and Erin N. Burton</i></p> <p>Chapter 72 T‐Cell Tumors 605<br /><i>Nariman Deravi, Stefan Keller, and Dorothee Bienzle</i></p> <p>Chapter 73 Mast Cell Neoplasia 626<br /><i>Melinda S. Camus</i></p> <p>Chapter 74 Histiocytic Proliferative Diseases of Dogs and Cats 633<br /><i>Peter F. Moore</i></p> <p><b>Section VI Platelets 649</b></p> <p>Chapter 75 Thrombopoiesis 651<br /><i>Mary K. Boudreaux and Pete W. Christopherson</i></p> <p>Chapter 76 Platelet Structure 658<br /><i>Mary K. Boudreaux and Pete W. Christopherson</i></p> <p>Chapter 77 Platelet Signal Transduction and Activation Response 667<br /><i>Pete W. Christopherson and Mary K. Boudreaux</i></p> <p>Chapter 78 Platelet Kinetics and Laboratory Evaluation of Thrombocytopenia 675<br /><i>Adi Wasserkrug‐Naor</i></p> <p>Chapter 79 Evaluation of Platelet Function 686<br /><i>Pete W. Christopherson and Marjory B. Brooks</i></p> <p>Chapter 80 Immune Thrombocytopenia 696<br /><i>Dana N. Levine and Marjory B. Brooks</i></p> <p>Chapter 81 Nonimmune‐Mediated Thrombocytopenia 709<br /><i>Julie Allen</i></p> <p>Chapter 82 Thrombocytosis and Essential Thrombocythemia 721<br /><i>Julie Allen and Tracy Stokol</i></p> <p>Chapter 83 von Willebrand Disease 731<br /><i>Marjory B. Brooks and James L. Catalfamo</i></p> <p>Chapter 84 Inherited Platelet Disorders 739<br /><i>Mary K. Boudreaux and Pete W. Christopherson</i></p> <p>Chapter 85 Acquired Platelet Dysfunction 747<br /><i>Benjamin M. Brainard</i></p> <p>Chapter 86 Treatment of Disorders of Platelet Number and Function 755<br /><i>Mary Beth Callan</i></p> <p><b>Section VII Hemostasis 763</b></p> <p>Chapter 87 Overview of Hemostasis 765<br /><i>Maureen A. Mcmichael</i></p> <p>Chapter 88 Laboratory Testing of Coagulation Disorders 787<br /><i>Marjory B. Brooks</i></p> <p>Chapter 89 Acquired Coagulopathies 804<br /><i>Marjory B. Brooks and Armelle De Laforcade</i></p> <p>Chapter 90 Hereditary Coagulopathies 812<br /><i>Marjory B. Brooks</i></p> <p>Chapter 91 Thrombotic Disorders 821<br /><i>Erica Behling‐Kelly and Robert Goggs</i></p> <p>Chapter 92 Disseminated Intravascular Coagulation 837<br /><i>Tracy Stokol</i></p> <p>Chapter 93 Vascular Diseases 848<br /><i>Sean P. Mcdonough</i></p> <p>Chapter 94 Treatment of Hemostatic Defects 855<br /><i>Robert Goggs and Alex M. Lynch</i></p> <p>Chapter 95 Avian Hemostasis 865<br /><i>Karen E. Russell and J. Jill Heatley</i></p> <p><b>Section VIII Transfusion Medicine 875</b></p> <p>Chapter 96 Erythrocyte Antigens and Blood Groups 877<br /><i>Marie‐Claude Blais and Maria Cecilia T. Penedo</i></p> <p>Chapter 97 Granulocyte and Platelet Antigens 891<br /><i>Jennifer S. Thomas</i></p> <p>Chapter 98 Principles of Canine and Feline Blood Collection, Processing, and Storage 898<br /><i>Anthony C. G. Abrams-Ogg and Shauna L. Blois</i></p> <p>Chapter 99 Red Blood Cell Transfusion in the Dog and Cat 908<br /><i>Mary Beth Callan</i></p> <p>Chapter 100 Transfusion of Plasma Products 914<br /><i>Marjory B. Brooks</i></p> <p>Chapter 101 Platelet and Granulocyte Transfusion 921<br /><i>Anthony C. G. Abrams‐Ogg, and Shauna L. Blois</i></p> <p>Chapter 102 Blood Transfusion in Large Animals 927<br /><i>Margaret C. Mudge</i></p> <p>Chapter 103 Blood Transfusion in Exotic Species 933<br /><i>Anneliese Strunk and Anke C. Stohr</i></p> <p>Chapter 104 Transfusion Reactions 940<br /><i>Nicole M. Weinstein</i></p> <p>Chapter 105 Cellular Therapy 948<br /><i>Steven E. Suter and Steven Dow</i></p> <p>Chapter 106 Clinical Use of Hematopoietic Growth Factors 957<br /><i>Steven E. Suter</i></p> <p>Chapter 107 Clinical Blood Typing and Crossmatching 964<br /><i>K. Jane Wardrop</i></p> <p><b>Section IX Species-Specific Hematology 969</b></p> <p>Chapter 108 Hematology of Dogs 971<br /><i>Maggie R. Mccourt and Theresa E. Rizzi</i></p> <p>Chapter 109 Hematology of Cats 983<br /><i>Deanna M. W. Schaefer</i></p> <p>Chapter 110 Hematology of Equids 993<br /><i>Kathleen P. Freeman, Alison J. Farr, and Annalisa Barrelet</i></p> <p>Chapter 111 Hematology of Bovids 1004<br /><i>R. Darren Wood</i></p> <p>Chapter 112 Hematology of Sheep and Goats 1012<br /><i>Jason Stayt</i></p> <p>Chapter 113 Hematology of Pigs 1019<br /><i>Catherine E. Thorn, Andrew S. Bowman, and David Eckersall</i></p> <p>Chapter 114 Hematology of Rodentia 1026<br /><i>Amy L. Macneill</i></p> <p>Chapter 115 Hematology of Mustelids 1034<br /><i>Stacy Clothier and Cathy Johnson‐Delaney</i></p> <p>Chapter 116 Hematology of Cavies 1043<br /><i>Samantha J. M. Evans and Kurt L. Zimmerman</i></p> <p>Chapter 117 Hematology of Lagomorphs 1050<br /><i>Francisco O. Conrado</i></p> <p>Chapter 118 Hematology of Laboratory Animals 1058<br /><i>Karyn E. Enos and David M. Moore</i></p> <p>Chapter 119 Hematology of Camelids 1073<br /><i>Susan J. Tornquist</i></p> <p>Chapter 120 Hematology of Cervids 1079<br /><i>Bridget C. Garner</i></p> <p>Chapter 121 Hematology of Paenungulata: Elephants, Sirenians, and Hyraxes 1090<br /><i>Emma H. Hooijberg</i></p> <p>Chapter 122 Hematology of Marine Mammals 1104<br /><i>Nicole I. Stacy and Hendrik H. Nollens</i></p> <p>Chapter and Hematology of Galliformes 1114<br /><i>Julie Piccione and Jessica Hokamp</i></p> <p>Chapter 124 Hematology of Psittacines 1127<br /><i>Diana Schwartz and Hugues Beaufrère</i></p> <p>Chapter 125 Hematology of Anseriformes 1140<br /><i>Jessica Hokamp and Julie Piccione</i></p> <p>Chapter 126 Hematology of Raptors 1148<br /><i>Jennifer Johns</i></p> <p>Chapter 127 Hematology of Ratites 1159<br /><i>Phillip Clark</i></p> <p>Chapter 128 Hematology of Elasmobranchs 1166<br /><i>Jill E. Arnold and Alexa Delaune</i></p> <p>Chapter 129 Hematology of Salmonids 1176<br /><i>Jere Stern</i></p> <p>Chapter 130 Hematology of Ictaluridae 1182<br /><i>Patricia Gaunt</i></p> <p>Chapter 131 Hematology of Cyprinidae 1188<br /><i>Ilze K. Berzins and Alexander E. Primus</i></p> <p>Chapter 132 Hematology of Lizards, Crocodilians, and Tuatara 1197<br /><i>Charlotte Hollinger and Jean A. Paré</i></p> <p>Chapter 133 Hematology of Serpentes 1209<br /><i>Laura J. Black and Marjorie Bercier</i></p> <p>Chapter 134 Hematology of Testudines 1219<br /><i>Jennifer D. Steinberg and Stephen J. Divers</i></p> <p>Chapter 135 Hematology of Amphibians 1228<br /><i>PERRY BAIN and KENDAL E. HARR</i></p> <p>Chapter 136 Hematology of Invertebrates 1233<br /><i>Jill E. Arnold</i></p> <p><b>Section X Quality Management and Laboratory Techniques 1241</b></p> <p>Chapter 137 Quality Management of Hematology Techniques 1243<br /><i>Martina Stirn and Kathleen P. Freeman</i></p> <p>Chapter 138 Total Error and Proficiency Testing 1255<br /><i>Sten Westgard and Kathleen P. Freeman</i></p> <p>Chapter 139 Quantitative Diagnostic Test Validation 1263<br /><i>Bente Flatland</i></p> <p>Chapter 140 Reference Intervals and Decision Limits 1273<br /><i>Kristen R. Friedrichs, Asger Lundorff Jensen, and Mads Kjelgaard‐Hansen</i></p> <p>Chapter 141 Bone Marrow Evaluation 1285<br /><i>Natali B. Bauer and Kendal E. Harr</i></p> <p>Chapter 142 Flow Cytometry 1295<br /><i>Unity Jeffery</i></p> <p>Chapter 143 Testing for Immune‐Mediated Hematologic Disease 1311<br /><i>K. Jane Wardrop, Melinda J. Wilkerson, and Cinzia Mastrorilli</i></p> <p>Chapter 144 Electrophoresis and Acute‐Phase Proteins 1320<br /><i>Alessia Giordano</i></p> <p>Chapter 145 Molecular Diagnostic Techniques 1331<br /><i>Robert J. Ossiboff</i></p> <p>Chapter 146 Genetic Evaluation of Inherited Hematologic Diseases 1337<br /><i>Noa Safra and Danika Bannasch</i></p> <p><b>Section 10 Glossary 1351</b></p> <p>Index 1353</p>

<p><b>The editors</b></p> <p><b>Marjory B. Brooks,</b> DVM, DACVIM, is Director of the Comparative Coagulation Laboratory at Cornell University’s Animal Health Diagnostic Center in Ithaca, New York, USA. <p><b>Kendal E. Harr,</b> DVM, MS, DACVP, is Owner and Clinical Pathologist at Urika, LLC in Mukilteo, Washington, USA. <p><b>Davis M. Seelig,</b> DVM, PhD, DACVP, is Associate Professor in the Department of Veterinary Clinical Sciences at the University of Minnesota College of Veterinary Medicine in St. Paul, Minnesota, USA. <p><b>K. Jane Wardrop,</b> DVM, MS, DACVP, is Professor in the Department of Veterinary Clinical Sciences at the College of Veterinary Medicine, Washington State University in Pullman, Washington, USA. <p><b>Douglas J. Weiss,</b> DVM, PhD, DACVP, is Emeritus Professor at the University of Minnesota College of Veterinary Medicine in St. Paul, Minnesota, USA.

<p><b>An updated guide to veterinary hematology with expanded coverage on a variety of topics</b></p> <p>The revised seventh edition of <i>Schalm’s Veterinary Hematology</i> is updated to provide a comprehensive review of all topics related to disorders of the blood in animals. Designed as a gold-standard reference, this text covers a wide range of species in both confined and free-range populations, reflects the most recent trends in hematology diagnostics, and discusses recent advances in traditional techniques. <p>Edited and written by an international team of experts in the field, the book represents an accessible yet in-depth resource for information on veterinary hematology. The new edition includes a hemolymphatic tissue section that covers current understanding of basic science and the species-specific hematology section is further expanded from previous editions. New chapters address emerging topics in hematology, and existing chapters have been revised and rearranged to improve readability and simplify access to the material. This seventh edition: <ul><li>Updates the most complete reference on veterinary hematology across species </li> <li>Contains a new section on basic biology of hemolymphatic tissues </li> <li>Expands coverage of species-specific hematology </li> <li>Presents new and emerging topics in blood disorders and diagnostic techniques</li> <li>Features a reorganized contents list for an integrated, easy to use reference</li></ul> <p>Written for veterinary clinical pathologists and residents, diagnostic laboratory staff, internists, and specialists, <i>Schalm’s Veterinary Hematology</i> is the most comprehensive and up-to-date reference on the topic.

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