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<p>List of Contributors ix</p> <p><b>Volume 1</b></p> <p>1 General View of the Cytoplasmic and Nuclear Features of Apoptosis 1<i><br />Humberto De Vitto, Juan P. Valencia, and James A. Radosevich</i></p> <p>2 Mitochondria in Focus: Targeting the Cell-Death Mechanism 13<br /><i>Humberto De Vitto, Roberta Palorini, Giuseppina Votta, and Ferdinando Chiaradonna</i></p> <p>3 Microbial Programmed Cell Death 49<br /><i>Neal D. Hammer</i></p> <p>4 Autophagy 71<br /><i>Mollie K. Rojas, Juel Chowdhury, Khatja Batool, Zane Deliu, and Abdallah Oweidi</i></p> <p>5 Cell Injury, Adaptation, and Necrosis 83<br /><i>Sarah G. Fitzpatrick and Sara C. Gordon</i></p> <p>6 Necroptosis 99<br /><i>Ben A. Croker, James A. Rickard, Inbar Shlomovitz, Arshed Al-Obeidi, Akshay A. D</i><i>’</i><i>Cruz, and Motti Gerlic</i></p> <p>7 Ferroptosis 127<br /><i>Ebru Esin Yoruker and Ugur Gezer</i></p> <p>8 Anoikis Regulation: Complexities, Distinctions, and Cell Differentiation 145<br /><i>Marco Beauséjour, Ariane Boutin, and Pierre H. Vachon</i></p> <p>9 Cornification 183<br /><i>Leopold Eckhart</i></p> <p>10 Excitotoxicity 197<br /><i>Julie Alagha, Sulaiman Alshaar, and Zane Deliu</i></p> <p>11 Molecular Mechanisms Regulating Wallerian Degeneration 205<br /><i>Mohammad Tauseef and Madeeha Aqil</i></p> <p>12 Pyronecrosis 225<br /><i>Maryam Khalili and James A. Radosevich</i></p> <p>13 Phenoptosis: Programmed Death of an Organism 237<br /><i>M.V. Skulachev and V.P. Skulachev</i></p> <p>14 Molecular Mechanisms Underlying Oxytosis 289<br /><i>Amalia M. Dolga, Sina Oppermann, Maren Richter, Birgit Honrath, Sandra Neitemeier, Anja Jelinek, Goutham Ganjam, and Carsten Culmsee</i></p> <p>15 Pyroptosis 317<br /><i>Kate E. Lawlor, Stephanie Conos, and James E. Vince</i></p> <p>16 Paraptosis 343<br /><i>Maryam Khalili and James A. Radosevich</i></p> <p>17 Hematopoiesis and Eryptosis 367<br /><i>Mollie K. Rojas, Chintan C. Gandhi, and Lawrence E. Feldman</i></p> <p><b>Volume 2</b></p> <p>18 Cyclophilin D-Dependent Necrosis 375<br /><i>Jatin Mehta and Chandi Charan Mandal</i></p> <p>19 Role of Phospholipases in Cell Death 395<br /><i>Manikanda Raja, Juel Chowdhury, and James A. Radosevich</i></p> <p>20 TRIAD (Transcriptional Repression-Induced Atypical Death) 411<br /><i>Takuya Tamura and Hitoshi Okazawa</i></p> <p>21 Alkylating-Agent Cytotoxicity Associated with O6-Methylguanine 427<br /><i>Latha M. Malaiyandi, Lawrence A. Potempa, Nicholas Marschalk, Paiboon Jungsuwadee, and Kirk E. Dineley</i></p> <p>22 Entosis 463<i><br />Jamuna A. Bai and Ravishankar Rai V.</i></p> <p>23 Mitotic Catastrophe 475<br /><i>Raquel De Souza, Lais Costa Ayub, and Kenneth Yip</i></p> <p>24 NETosis and ETosis: Incompletely Understood Types of Granulocyte Death and their Proposed Adaptive Benefits and Costs 511<br /><i>Marko Radic</i></p> <p>25 Parthanatos: Poly ADP Ribose Polymerase (PARP)-Mediated Cell Death 535<br /><i>Amos Fatokun</i></p> <p>26 Methuosis: Drinking to Death 559<br /><i>Madeeha Aqil</i></p> <p>27 Oncosis 567<br /><i>Priya Weerasinghe, Sarathi Hallock, Robert Brown, and L. Maximilian Buja</i></p> <p>28 Autoschizis: A Mode of Cell Death of Cancer Cells Induced by a Prooxidant Treatment In Vitro and In Vivo 583<br /><i>J. Gilloteaux, J.M. Jamison, D. Arnold, and J.L. Summers</i></p> <p>29 Programmed Death 1 (PD1)-Mediated T-Cell Apoptosis and Cancer Immunotherapy 695<br /><i>Chandi Charan Mandal, Jatin Mehta, and Vijay K. Prajapati</i></p> <p> </p>

<p><b>About the Editor</b> <p><b>JAMES A. RADOSEVICH, PH. D.</b> is a Professor and Staff Research Scientist at the University of Illinois, Dental College and Cancer Center/VA, Chicago Health Care System. He is also an Affiliate Professor at Roosevelt University, College of Pharmacy, Department of Biopharmaceutical Sciences, USA.

<p><b>APOPTOSIS AND BEYOND: THE MANY WAYS CELLS DIE</b> <p><b>These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death</b> <p>This two-volume set is the first comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field and stimulate their thinking by looking at these pathways when their research system does not show classic signs of apoptotic pathway activation. In addition, it links activities like the molecular biology of one process to another (e.g. Necrosis to Apoptosis) and contrasts those that are closely related. <p>Volume 1 of <i>Apoptosis and Beyond: The Many Ways Cells Die</i> begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers subjects such as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. <ul> <li>Covers all the known processes that dying cells undergo</li> <li>Provides extensive coverage of a topic not fully covered before</li> <li>Offers chapters written by top researchers in the field</li> <li>Provides activities that link and contrast processes to each other</li> </ul> <p><i>Apoptosis and Beyond: The Many Ways Cells Die</i> will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

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