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<p>Contributors ix</p> <p>Preface to the fourth edition xiii</p> <p>Further reading xv</p> <p>Acknowledgments xvi</p> <p>1 Beginnings: the molecular pathology of hemoglobin 1<br /><i>David Weatherall</i></p> <p>2 Stem cells 21<br /><i>David T. Scadden</i></p> <p>3 The genetics of acute myeloid leukemias 37<br /><i>Amy M. Trottier & Carolyn J. Owen</i></p> <p>4 Molecular diagnostics and risk assessment in myeloid malignancies 49<br /><i>Christian Scharenberg & Torsten Haferlach</i></p> <p>5 Molecular basis of acute lymphoblastic leukemia 59<br /><i>Bela Patel & Fiona Fernando</i></p> <p>6 Chronic myeloid leukemia 71<br /><i>Hagop Kantarjian, Jorge Cortes, Elias Jabbour & Susan O’Brien</i></p> <p>7 Myeloproliferative neoplasms 87<br /><i>Jyoti Nangalia, Anthony J. Bench, Anthony R. Green & Anna L. Godfrey</i></p> <p>8 Lymphoma genetics 101<br /><i>Jennifer L. Crombie, Anthony Letai & John G. Gribben</i></p> <p>9 The molecular biology of chronic lymphocytic leukemia 111<br /><i>John G. Gribben</i></p> <p>10 The molecular biology of multiple myeloma 121<br /><i>Wee Joo Chng & P. Leif Bergsagel</i></p> <p>11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 131<br /><i>Deena Iskander, Lucio Luzzatto & Anastasios Karadimitris</i></p> <p>12 Anemia of chronic disease 155<br /><i>Tomas Ganz</i></p> <p>13 The molecular basis of iron metabolism 161<br /><i>Nancy C. Andrews & Tomas Ganz</i></p> <p>14 Hemoglobinopathies due to structural mutations 173<br /><i>D. Mark Layton & Steven Okoli</i></p> <p>15 Molecular pathogenesis of malaria 193<br /><i>David J. Roberts, Arnab Pain & Chetan E. Chitnis</i></p> <p>16 Molecular coagulation and thrombophilia 207<br /><i>Bj</i><i>örn Dahlb</i><i>äck & Andreas Hillarp</i></p> <p>17 The molecular basis of hemophilia 221<br /><i>Daniel P. Hart & Paul L.F. Giangrande</i></p> <p>18 The molecular basis of von Willebrand disease 235<br /><i>Luciano Baronciani</i></p> <p>19 Platelet disorders 251<br /><i>Kenneth J. Clemetson</i></p> <p>20 The molecular basis of blood cell alloantigens 267<br /><i>Cristina Navarrete, Louise Tilley, Winnie Chong & Colin J. Brown</i></p> <p>21 Functions of blood group antigens 285<br /><i>Jonathan S. Stamler & Marilyn J. Telen</i></p> <p>22 Autoimmune hematological disorders 297<br /><i>Drew Provan & John W. Semple</i></p> <p>23 Molecular therapeutics in hematology: gene therapy 319<br /><i>William M. McKillop & Jeffrey A. Medin</i></p> <p>24 Pharmacogenomics 339<br /><i>Leo Kager & William E. Evans</i></p> <p>25 History and development of molecular biology 353<br /><i>Paul Moss</i></p> <p>26 Cancer stem cells 363<br /><i>Sara Ali & Dominique Bonnet</i></p> <p>27 Molecular basis of transplantation 373<br /><i>Francesco Dazzi & Antonio Galleu</i></p> <p>Index 389</p>

<p><b>DREW PROVAN, MD, FRCP, FRCPath,</b> is Emeritus Reader in Autoimmune Haematology, Department of Haematology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK. <p><b>JOHN G. GRIBBEN, MD, DSc, FRCP, FRCPath, FMedSci,</b> is The Gordon Hamilton Fairley Professor of Medical Oncology, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.

<p><b>The new and fully-revised volume of molecular GRIBBEN biological techniques for practicing and trainee hematologists</b> <p><i>Molecular Hematology</i> is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant???molecular techniques are continuing to play a central role in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins. <p>Now in its fourth edition, <i>Molecular Hematology</i> has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others. <ul> <li>Demonstrates the clinical relevance of molecular biology in hematology</li> <li> Provides overviews of recent advances in cancer cell biology, with an emphasis on leukemia and lymphoma</li> <li> Offers new and updated chapters written by an international team of experts</li> <li>Presents new full-color charts, graphs, and illustrations</li> <li> Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools </li> </ul> <p><i>Molecular Hematology</i> is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.

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