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Biomarkers in Cancer Screening and Early Detection


Biomarkers in Cancer Screening and Early Detection


Translational Oncology 1. Aufl.

von: Sudhir Srivastava

132,99 €

Verlag: Wiley-Blackwell
Format: PDF
Veröffentl.: 05.06.2017
ISBN/EAN: 9781118468838
Sprache: englisch
Anzahl Seiten: 320

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Beschreibungen

<p>Prepared by world leaders on this topic, <i>Biomarkers in Cancer Screening and Early Detection</i> offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment.</p> <ul> <li>Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers</li> <li>Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward</li> <li>Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers</li>
<p>List of Contributors, ix</p> <p>Preface, xiii</p> <p><b>Part I Foundations of Biomarker Research</b></p> <p>1 Nuts and Bolts of Biomarker Research, 3<br /><i>Sharmistha Ghosh and Sudhir Srivastava</i></p> <p>2 Cancer Genome Methylation: Biology, Biomarker and Therapeutic Opportunities, 16<br /><i>Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi</i></p> <p>3 MicroRNA Biomarkers for Early Detection of Cancer, 27<br /><i>WendyWang, Matthew R Young, and Sudhir Srivastava</i></p> <p>4 Inflammation and Cancer, 37<br /><i>Pamela L Beatty, Sandra Cascio, and Olivera J Finn</i></p> <p>5 Exosomes: A Valuable Biomedical Tool in Biomarker Discovery and Development, 50<br /><i>Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava</i></p> <p>6 Epithelial-to-Mesenchymal Transition (EMT): Clinical Implications, 64<br /><i>Elisa CWoodhouse and Suresh Mohla</i></p> <p><b>Part II State-of-the-Science in Organ-Specific Biomarker Research</b></p> <p>7 Breast Cancer, 77<br /><i>Benjamin A Katchman, Christos Patriotis, and Karen S Anderson</i></p> <p>8 Ovarian Cancer, 93<br /><i>Christos Patriotis, Archana Simmons, Karen H Lu, Robert C Bast, Jr, and Steven J Skates</i></p> <p>9 Esophageal Cancer Biomarkers, 104<br /><i>Yanxin Luo, Kishore Guda, SanfordD Markowitz, Amitabh Chak, Andrew M Kaz, andWilliam M Grady</i></p> <p>10 Predictive Biomarkers for Therapy in Adenocarcinoma of the Upper Digestive Tract, 118<br /><i>Heath D Skinner, Qiongrong Chen, Elena Elimova, RoopmaWadhwa, Shumei Song, and Jaffer A Ajani</i></p> <p>11 Pancreatic Cancer, 130<br /><i>Sam CWang and Peter J Allen</i></p> <p>12 Colon Cancer, 141<br /><i>Paul DWagner</i></p> <p>13 Prognostic and Predictive Biomarkers for Colorectal Cancer, 151<br /><i>Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava</i></p> <p>14 Early Detection of Lung Cancer, 163<br /><i>Mohamed Hassanein, Melinda C Aldrich, Stephen A Deppen, Karl E Krueger, Eric L Grogan, and Pierre P Massion</i></p> <p>15 Commonalities in Lung Cancer and COPD, 185<br /><i>MalgorzataWojtowicz and Eva Szabo</i></p> <p>16 Prostate Cancer, 197<br /><i>Jacob Kagan, Ian M Thompson, and</i> <i>DanielWChan</i></p> <p><b>Part III Biomarkers, Screening and Precision Health: Implications for Public Health</b></p> <p>17 Improving the Clinical Validity of Biomarker Research in Cancer Detection, 209<br /><i>David F Ransohoff</i></p> <p>18 Cancer Overdiagnosis, Ramifications and Research Strategies, 220<br /><i>Barbara K Dunn and Barnett S Kramer</i></p> <p>19 Predictive Markers and Driver Genes From Treatment Trials: Potential Utility For Early Diagnosis, 231<br /><i>Brian S Sorg, Sarfraz Memon, Kelly Y</i> <i>Kim, Aniruddha Ganguly, Tracy Lively,</i> <i>James Tricoli, Magdalena Thurin,</i> <i>Lokesh Agrawal, Tawnya C McKee,</i> <i>Barbara A Conley, and J Milburn Jessup</i></p> <p>20 Statistical Consideration in Predictive and Prognostic Markers, 245<br /><i>Fei Ye and Yu Shyr</i></p> <p>21 Clinical Validation of Molecular Biomarkers in Translational Medicine, 256<br /><i>Harry B Burke and William E Grizzle</i></p> <p>22 Cancer Biomarker Assays: Performance Standards, 267<br /><i>Anna K Fuzery and Daniel W Chan</i></p> <p>23 Bioethics and Cancer Biomarker Research, 277<br /><i>Nathan Nobis, William Grizzle, and</i> <i>Stephen Sodeke</i></p> <p>24 Colon Cancer Screening, 283<br /><i>Molly Perencevich, Jennifer Inra, and</i> <i>Sapna Syngal</i></p>
<p><b> Edited by<br> Sudhir Srivastava, Ph.D., MPH</b> Senior Scientific Officer, Chief, Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA <p><b> Translational Oncology Series<br> Series Editors<br> ROBERT C. BAST, MD,</b> Vice President for Translational Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA <p><b> MAURIE MARKMAN, MD,</b> Senior Vice President for Clinical Affairs, Cancer Treatment Centers of America, Clinical Professor of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA <p><b> ERNEST HAWK, MD, MPH,</b> Vice President, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
<p><i> Biomarkers in Cancer Screening and Early Detection</i> offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and clinical use. The primary purpose of this book is to summarize and present best practices in this field to date, and offer actionable information – and hopefully also inspiration – to move discovery and clinical application forward. <p> This latest volume of the <i>Translational Oncology series, Biomarkers in Cancer Screening and Early Detection</i> is organized into three sections: Section I lays the foundation for biomarker discovery, development and validation. Section II presents organ-specific topics relevant to the clinical needs in early detection, the natural history of the disease and associated evidence in support of biomarker research, an overview of the current state-of-the art in biomarker research, current progress toward bringing these biomarkers into clinical use and the future of biomarker-based screening and early detection for the respective organ type. Finally, Section III offers chapters that address the current screening strategies for selected organ types, discuss deficiencies with the present practice and identify clinical needs that may benefit from biomarker-based approaches. <p> This latest volume of the <i>Translational Oncology series, Biomarkers in Cancer Screening and Early Detection:</i> <ul> <li>Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward</li> <li>Considers the cutting edge "bench to bedside and back" breakthroughs which have transformed the diagnosis, prognosis and treatment of cancer</li> <li>Discusses screening guidelines, research strategies, and issues surrounding cancer overdiagnosis</li> <li>Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers</li> </ul> <br> <p> The development of cancer is preceded by numerous mutations and changes which transform normal cells into benign tumors, and progressively into malignant and metastatic forms. This enormous complexity makes cancer detection, diagnosis, and treatment challenging and therefore the ability to identify tumors that are destined to progress at an early stage will allow effective treatment interventions and reduce deaths. This new book comprehensively summarises the current state of play and is an ideal resource for clinical and research oncologists interested in the progress of screening and detection of cancer.

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