Details

Histologic Basis of Ocular Disease in Animals


Histologic Basis of Ocular Disease in Animals


1. Aufl.

von: Bruce Grahn, Robert Peiffer, Brian Wilcock

218,99 €

Verlag: Wiley-Blackwell
Format: EPUB
Veröffentl.: 30.08.2018
ISBN/EAN: 9781118388792
Sprache: englisch
Anzahl Seiten: 464

DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.

Beschreibungen

<p><i>Histologic Basis of Ocular Disease in Animals</i> is a comprehensive reference covering pathology of the eye in a spectrum of animal species, including domestic animals, fish, birds, and laboratory animals.</p> <ul> <li>Offers a comprehensive resource on diseases and conditions of the eye and orbit in a wide range of species</li> <li>Covers domestic animals, fish, birds, and laboratory animals</li> <li>Presents more than 1200 high-quality images carefully selected to illustrate the ocular conditions covered</li> <li>Emphasizes unique pathological responses where necessary</li> </ul>
<p>Foreword xiii</p> <p>Acknowledgements xv</p> <p><b>1 Fixation and processing of ocular tissues 1</b></p> <p>Fixatives 1</p> <p>Fixation and sectioning artifacts 2</p> <p>Fixation techniques 3</p> <p>Trimming the fixed globe 5</p> <p>Electron microscopy 13</p> <p>References 14</p> <p><b>2 General pathology of the eye 15</b></p> <p>Adaptations characterized by changes in cell size, number, or appearance 15</p> <p>Neoplasia 19</p> <p>Nomenclature 23</p> <p>Distinguishing benign from malignant 25</p> <p>Prognostication 27</p> <p>Unsuccessful adaptation: cellular degeneration, necrosis, and apoptosis 27</p> <p>Calcification, pigmentation, and cystic change 30</p> <p>Ocular inflammation 32</p> <p>Ocular manifestations of acute inflammation 34</p> <p>Chronic inflammation 39</p> <p>Ocular manifestations of chronic inflammation 39</p> <p>Immune privilege 41</p> <p>Lymphocytic–plasmacytic endophthalmitis 42</p> <p>The sequelae of intraocular inflammation and other injuries 43</p> <p>Limited regenerative ability 43</p> <p>Susceptibility to scarring 43</p> <p>Further reading 46</p> <p><b>3 Congenital anomalies 49</b></p> <p>Introduction 49</p> <p>Defective organogenesis 50</p> <p>Defective early organogenesis 50</p> <p>Anophthalmos and cystic globe 53</p> <p>Anophthalmos and microphthalmos 54</p> <p>Cyclopia and synophthalmos 56</p> <p>Congenital anomalies of lens 56</p> <p>Congenital retinal nonattachment 63</p> <p>Aniridia – iridal hypoplasia or aplasia 63</p> <p>Coloboma 63</p> <p>Defective later organogenesis 64</p> <p>Neurectodermal defects 64</p> <p>Multifocal retinopathies 71</p> <p>Multiple ocular anomalies (MOA) in Rocky Mountain horses 71</p> <p>Anomalies of surface ectodermal origin that develop during later organogenesis 73</p> <p>Congenital adnexal cysts 73</p> <p>Dermoids 73</p> <p>Defects of neural crest migration and mesenchymal differentiation that develop in later organogenesis 73</p> <p>Congenital corneal disease 73</p> <p>Congenital disorders of neurocrest and mesenchymal tissues that manifest in the uvea during later organogenesis 74</p> <p>Persistent pupillary membranes (PPMs) 74</p> <p>Congenital glaucoma 75</p> <p>Uveal hypoplasia 78</p> <p>Collie eye anomaly (CEA) and related defects 78</p> <p>Persistence of embryonic vasculature 81</p> <p>References 83</p> <p><b>4 Histopathology of ocular trauma 89</b></p> <p>Perforating and penetrating wounds of the globe and ocular tissues 89</p> <p>Perforating wounds of the globe 89</p> <p>Traumatic intraocular hemorrhage 89</p> <p>Expulsive subchoroidal hemorrhage 90</p> <p>Sequelae of intraocular hemorrhage 90</p> <p>Posttraumatic inflammation 95</p> <p>Phacoclastic endophthalmitis and traumatic cataract 95</p> <p>Infectious endophthalmitis 95</p> <p>Trauma to individual ocular tissues 95</p> <p>Orbit and optic nerve 95</p> <p>Cornea/sclera 95</p> <p>Uvea 100</p> <p>Lens 101</p> <p>Vitreous and retina 101</p> <p>Globe as a whole 101</p> <p>Reaction to foreign materials 101</p> <p>Complications of ocular surgery 102</p> <p>Chemical and thermal burns 102</p> <p>Effects of radiant energy 103</p> <p>References 103</p> <p><b>5 Diseases of the eyelid, conjunctiva, lacrimal, and nasolacrimal systems 105</b></p> <p>Eyelids 105</p> <p>Structural disorders 105</p> <p>Dermoids 105</p> <p>Hamartomas 105</p> <p>Subconjunctival fat prolapse 105</p> <p>Entropion, ectropion, and medial canthal pocket syndrome 105</p> <p>Distichiasis, districhiasis, and ectopic cilia 106</p> <p>Inflammatory disease 108</p> <p>Pyogranulomatous (granulomatous) blepharitis 108</p> <p>Juvenile sterile granulomatous dermatitis and lymphadenitis (juvenile cellulitis) 110</p> <p>Chalazion 110</p> <p>Medial canthal erosion syndrome 111</p> <p>Proliferative pox virus blepharitis in birds 111</p> <p>Parasitic eyelid disorders 111</p> <p>Demodicosis 111</p> <p>Cnemidocoptes pilae (scaly beak) infestation of avian species 113</p> <p>Eyelid tumors and neoplasms 113</p> <p>Cystic apocrine hyperplasia (hidrocystomas, sudoriferous cysts, and apocrine cysts) 113</p> <p>Granular cell tumor 113</p> <p>Meibomian (tarsal gland) adenoma 115</p> <p>Melanocytoma and melanoma 115</p> <p>Histiocytoma 118</p> <p>Mast cell tumor 118</p> <p>Peripheral nerve sheath tumors 118</p> <p>Equine sarcoid 121</p> <p>Squamous cell carcinoma 122</p> <p>Diseases of the conjunctiva 123</p> <p>General pathology of the conjunctiva 124</p> <p>Congenital conjunctival abnormalities 124</p> <p>Infectious conjunctivitis 126</p> <p>Herpesvirus 126</p> <p>Chlamydophila (chlamydia) 126</p> <p>Rickettsia rickettsi 126</p> <p>Moraxella bovis 126</p> <p>Parasitic conjunctivitis 126</p> <p>Noninfectious inflammatory disease 127</p> <p>Episclerokerataconjunctivitis 127</p> <p>Lipogranulomatous conjunctivitis of cats 127</p> <p>Eosinophilic conjunctivitis 128</p> <p>Miscellaneous conjunctival disorders 128</p> <p>Conjunctival overgrowth in rabbits (pseudopterygium) 128</p> <p>Membranous (ligneous) conjunctivitis 129</p> <p>Conjunctival neoplasms 129</p> <p>Conjunctival lymphoma 129</p> <p>Conjunctival mast cell tumors 130</p> <p>Conjunctival melanoma and melanocytoma 130</p> <p>Viral papillomas 133</p> <p>Conjunctiva squamous papilloma 133</p> <p>Conjunctival squamous cell carcinoma 133</p> <p>Conjunctival vascular neoplasia 133</p> <p>Miscellaneous neoplasms of the third eyelid 133</p> <p>Lacrimal and nasolacrimal disorders 136</p> <p>Neoplasms of the gland of the third eyelid 136</p> <p>Prolapsed gland of the third eyelid 138</p> <p>Keratoconjunctivitis sicca (KCS) 138</p> <p>Dacryops and canaliculops 138</p> <p>References 138</p> <p><b>6 Diseases of the cornea 143</b></p> <p>Corneal wound healing 143</p> <p>Epithelial wound healing 143</p> <p>Stromal wound healing 147</p> <p>Endothelial wound healing 149</p> <p>Epithelial and fibrous ingrowth 151</p> <p>Healing of corneal grafts 152</p> <p>Nonspecific corneal responses to insult 152</p> <p>Corneal vascularization 152</p> <p>Corneal pigmentation 154</p> <p>Corneal edema 154</p> <p>Keratitis 154</p> <p>Epithelial alterations of keratitis 154</p> <p>Stromal alterations of keratitis 156</p> <p>Endothelialitis 158</p> <p>Specific inflammatory corneal disease 159</p> <p>Immune‐mediated nonulcerative keratitis 159</p> <p>Immune‐mediated ulcerative keratitis 159</p> <p>Superficial punctate keratitis (punctate erosive corneal dystrophy) 159</p> <p>Chronic superficial keratitis (pannus) 159</p> <p>Eosinophilic keratitis 161</p> <p>Miscellaneous corneal disorders: corneal sequestrum, indolent corneal ulceration, corneal dystrophy, corneal lipid infiltrates, and corneal degeneration 161</p> <p>Corneal sequestrum 161</p> <p>Indolent ulceration (boxer ulcer, spontaneous corneal epithelial defects) 164</p> <p>Corneal dystrophies, corneal lipid infiltrates, and corneal calcific/lipid degeneration 165</p> <p>Miscellaneous corneal disease 167</p> <p>Corneal neoplasia 172</p> <p>References 177</p> <p><b>7 Diseases of the episclera and sclera 181</b></p> <p>Primary episcleral and scleral inflammatory disorders: a brief introduction 181</p> <p>Secondary scleritis 181</p> <p>Scleral neoplasia 182</p> <p>Limbal melanocytoma 184</p> <p>Episcleritis (episclerokeratitis, episclerokeratoconjunctivitis) 185</p> <p>Scleritis and necrotizing scleritis a continuum or separate conditions? 189</p> <p>Non‐necrotizing scleritis 193</p> <p>Necrotizing scleritis 195</p> <p>Parasitic episcleral disease (onchocerca vulpis/lienalis) 195</p> <p>References 196</p> <p><b>8 Histologic manifestations of disorders of the uvea 197</b></p> <p>Normal aging changes 203</p> <p>Degenerative diseases of the uvea 205</p> <p>Uveal atrophy 205</p> <p>Uveal cysts 205</p> <p>Cystoid degeneration of the pars plana ciliary epithelium 205</p> <p>Pre‐iridal fibrovascular membranes (PIFMs) 208</p> <p>Heterotopic bony metaplasia of the ciliary body in guinea pigs 208</p> <p>Uveitis 210</p> <p>The nomenclature of uveitis 210</p> <p>The intraocular events of uveitis 210</p> <p>The etiologic implications of inflammatory exudates 216</p> <p>Immune privilege 218</p> <p>Consequences of uveitis 218</p> <p>Histologic basis of the common infectious, idiopathic, and immune‐mediated uveitis syndromes in domestic animals 221</p> <p>Lens‐induced uveitis 221</p> <p>Phacolytic uveitis 223</p> <p>Phacoclastic uveitis 224</p> <p>Equine recurrent uveitis 227</p> <p>Feline lymphocytic–plasmacytic uveitis 231</p> <p>Pigmentary uveitis/pigmentary glaucoma of dogs 231</p> <p>Equine heterochromic iridocyclitis with secondary keratitis 233</p> <p>Vogt–Koyanagi–Harada‐like or uveodermatologic syndrome in dogs 233</p> <p>Uveal xanthogranuloma in miniature schnauzers 235</p> <p>Uveitis associated with specific infectious agents 235</p> <p>Viruses 235</p> <p>Feline infectious peritonitis 235</p> <p>Canine adenovirus‐associated uveitis 238</p> <p>Canine distemper virus‐associated uveitis 239</p> <p>Bovine malignant catarrhal fever (MCF)‐associated uveitis 239</p> <p>Bovine viral diarrhea mucosal disease‐associated uveitis 239</p> <p>Ovine bluetongue 239</p> <p>Equine viral arteritis (EVA)‐associated uveitis 239</p> <p>West Nile‐associated avian uveitis 239</p> <p>Hog cholera 239</p> <p>Bacteria 240</p> <p>Fungi 241</p> <p>Other infectious causes for endophthalmitis 245</p> <p>Algal endophthalmitis 246</p> <p>Protozoan endophthalmitis 246</p> <p>Metazoan parasitic uveitis 246</p> <p>References 250</p> <p><b>9 Histologic basis of glaucoma 255</b></p> <p>Introduction 255</p> <p>The gross, subgross, and histologic lesions of elevated IOP 255</p> <p>Retinal changes 257</p> <p>Optic nerve changes 262</p> <p>Classification of canine glaucoma and introduction to open and closed angles 266</p> <p>Congenital glaucoma 267</p> <p>Primary glaucoma 270</p> <p>Open angle glaucoma of beagle dogs 274</p> <p>Primary (congenital) glaucoma in New Zealand white rabbit 274</p> <p>Secondary glaucoma 274</p> <p>Pre‐iridal Fibrovascular Membrane 274</p> <p>Posterior Synechia with Pupillary Block 275</p> <p>Vitreous degeneration, syneresis, and anterior chamber prolapse 275</p> <p>Trabecular obstruction by tumor 278</p> <p>Other causes of secondary glaucoma in dogs 278</p> <p>Glaucoma in cats 283</p> <p>Glaucoma in horses 284</p> <p>References 286</p> <p><b>10 Histologic manifestations of acquired and inherited diseases of the lens 289</b></p> <p>Embryology and anatomy of the lens 289</p> <p>Physiology of the lens 292</p> <p>Pathology of the lens 292</p> <p>Aging changes 294</p> <p>Cataract 294</p> <p>The classification of cataracts 294</p> <p>The histopathology of cataract 294</p> <p>The pathogenesis of cataracts 299</p> <p>Etiologies of cataract 299</p> <p>Lens luxation 302</p> <p>Inherited lens zonular dysplasia 303</p> <p>References 305</p> <p><b>11 Acquired diseases of the vitreous 307</b></p> <p>Primary disorders of the vitreous 310</p> <p>Vitreous degeneration 310</p> <p>Asteroid hyalosis 315</p> <p>Posterior vitreous detachment 315</p> <p>Synchisis scintillans 315</p> <p>Uveal and neuroectodermal pigment and cysts within the vitreous and incidental parasitic encounters 317</p> <p>Neovascularization 317</p> <p>Conditions with secondary vitreous involvement 317</p> <p>Vitritis 317</p> <p>Vitreous hemorrhage 319</p> <p>References 322</p> <p><b>12 Histologic manifestations of retinal disease 325</b></p> <p>Introduction 325</p> <p>Retinal diseases by histologic pattern 328</p> <p>Retinal atrophy 329</p> <p>Inner retinal atrophies 329</p> <p>The pathogenesis of retinal degeneration secondary to glaucoma 329</p> <p>Retinal atrophy secondary to non‐glaucomatous optic nerve injury and vascular disease 335</p> <p>Optic nerve hypoplasia/aplasia 336</p> <p>Outer retinal (photoreceptor) atrophies 336</p> <p>Inherited photoreceptor dysplasias and degenerations 336</p> <p>Retinal detachment 340</p> <p>Toxic and nutritional retinopathies 346</p> <p>Fluoroquinolone‐induced retinal degeneration 346</p> <p>Vitamin A deficiency 347</p> <p>Vitamin E deficiency 347</p> <p>Taurine deficiency 347</p> <p>Light‐induced retinal degeneration 347</p> <p>Sudden acquired retinal degeneration (SARD) and immune mediated retinopathy (IMR) of dogs 352</p> <p>Diseases targeting the retinal pigment epithelium 352</p> <p>Retinal pigment epithelial dystrophy (central progressive retinal atrophy) 352</p> <p>Hereditary retinal pigment epithelial disorders (congenital stationary night blindness of briard dogs, multifocal retinopathies) 352</p> <p>Canine multifocal retinopathy 354</p> <p>Retinal pigment epithelial dysplasia in the royal college of surgeons rat 354</p> <p>Localized chorioretinal atrophy in rats 354</p> <p>Retinitis 354</p> <p>Bystander retinitis 356</p> <p>Retinitis as a manifestation of neurologic disease 356</p> <p>Histophilus somni (formerly Hemophilus somnus) infection in cattle 356</p> <p>Canine distemper 356</p> <p>Retinal lesions reflecting noninfectious systemic disease 357</p> <p>Retinal lesions of systemic hypertension 357</p> <p>Retinal lesions resulting from inborn errors in the intermediary metabolism (lysosomal storage diseases and others) 357</p> <p>Retinal injury from thermal energy 358</p> <p>Retinal neoplasms 358</p> <p>Medullopitheliomas 360</p> <p>Retinoblastoma 360</p> <p>References 360</p> <p><b>13 Acquired diseases of the optic nerve 367</b></p> <p>Intraocular disorders with associated optic neuropathy 367</p> <p>Glaucomatous optic neuropathy 367</p> <p>Endophthalmitis and ascending optic neuritis 372</p> <p>Canine distemper optic neuritis 372</p> <p>Orbital disorders that affect the optic nerve 372</p> <p>Proptotic optic neuropathy 372</p> <p>Orbital cellulitis/abscess with optic nerve sepsis 372</p> <p>CNS conditions that affect the optic nerve 372</p> <p>Optic nerve disorders 376</p> <p>Granulomatous meningoencephalitis 376</p> <p>Unilateral granulomatous optic neuritis 376</p> <p>Optic neuropathy in horses 376</p> <p>Feline optic neuropathies 376</p> <p>Other causes of optic neuritis 378</p> <p>Toxic optic neuropathy 378</p> <p>Vitamin A deficiency 379</p> <p>Primary optic nerve neoplasms 381</p> <p>Meningioma 381</p> <p>Optic nerve gliomas 382</p> <p>Peripapillary medulloepitheliomas 382</p> <p>Lymphosarcoma and other metastatic neoplasms 382</p> <p>References 384</p> <p><b>14 Acquired diseases of the orbit 387</b></p> <p>Introduction 387</p> <p>Inflammatory disease 387</p> <p>Extraocular myositis 388</p> <p>Lacrimal adenitis 389</p> <p>Orbital trauma/hematoma 390</p> <p>Zygomatic sialocoele 391</p> <p>Orbital cysts and post‐enucleation orbital mucocoeles 393</p> <p>Parasitic orbital disease 396</p> <p>Orbital neoplasia 396</p> <p>Multilobular tumor of bone (multilobular osteochondroma) 398</p> <p>Primary orbital osteoma and osteosarcoma 402</p> <p>Lacrimal adenoma and adenocarcinoma 404</p> <p>Harderian gland adenomas and adenocarcinomas 404</p> <p>Rhabdomyosarcoma 404</p> <p>Orbital myofibroblastic sarcoma 404</p> <p>Vascular anomalies 406</p> <p>References 406</p> <p><b>15 Intraocular neoplasia 409</b></p> <p>Non‐neoplastic hyperpigmented lesions 410</p> <p>Benign melanocytic neoplasia 410</p> <p>Uveal melanocytoma 410</p> <p>Uveal melanocytosis (melanosis) 415</p> <p>Malignant uveal melanomas 415</p> <p>Canine and feline uveal malignant melanoma 415</p> <p>Diffuse iris melanoma of cats 417</p> <p>Iris and ciliary epithelial neoplasia 422</p> <p>Medulloepithelioma and retinoblastoma (primitive neuroectodermal tumors) 426</p> <p>Primary ocular sarcomas of cats and rabbits 428</p> <p>Schwannomas of blue eyed dogs 430</p> <p>Osteosarcoma and chondrosarcoma 430</p> <p>Miscellaneous primary intraocular tumors 432</p> <p>Metastatic uveal neoplasia 433</p> <p>Lymphosarcoma 433</p> <p>Secondary intraocular neoplastic extension from primary nasal and orbital and adnexal neoplasms 435</p> <p>References 436</p> <p>Index 443</p>
<p>"Throughout this superbly illustrated textbook, the authors use a combination of histology, gross specimens, and many clinical examples to describe ocular diseases and their underlying pathophysiology...Overall, this book is a valuable and fairly priced resource for veterinary students, veterinarians, and pathologists." <b>JAVMA, MAR 15, 2019, VOL 254, NO. 6</b></p>
<p><b>Bruce Grahn, DVM, Diplomate ACVO, ABVP,</b> is Professor Emeritus of Veterinary Ophthalmology at the Western College of Veterinary Medicine, Prairie Ocular Pathology Service, University of Saskatchewan in Saskatoon, Saskatchewan, Canada.</p> <p><b>Robert Peiffer, DVM, PhD, Diplomate ACVO,</b> is Professor Emeritus of Ophthalmology and Pathology, School of Medicine at the University of North Carolina in Chapel Hill, North Carolina, USA.</p> <p><b>Brian Wilcock, DVM, PhD, Honorary Diplomate ACVO,</b> is Professor Emeritus of Pathology, Ontario Veterinary College at the University of Guelph and Owner of Histovet Surgical Pathology in Guelph, Ontario, Canada.</p>
<p><b>Histologic Basis of Ocular Disease in Animals</b> <p><i>Histologic Basis of Ocular Disease in Animals</i> is a comprehensive reference covering pathology of the eye in a spectrum of animal species, including domestic animals, fish, birds, and laboratory animals. With more than 1200 high-quality gross, subgross, and histological images carefully chosen to depict the ocular conditions discussed, the book provides a well-illustrated resource on ocular pathology. Focusing on pathology applicable to the eye in a variety of species, unique pathological responses are highlighted where appropriate. <p>The book presents introductory chapters on handling and processing of ocular tissues and the general pathology of ocular disease. Subsequent chapters highlight the clinical, gross, and histopathologic details of ocular conditions by pathogenesis, tissue, and disease process. The breadth of material is enhanced by pertinent clinical perspectives and extensive references. <ul> <li> Offers a comprehensive resource on diseases and conditions of the eye and orbit in a wide range of species</li> <li> Covers domestic animals, fish, birds, and laboratory animals</li> <li> Presents more than 1200 high-quality images carefully selected to illustrate the ocular conditions covered</li> <li> Emphasizes unique pathological responses where necessary</li> </ul> <p><i>Histologic Basis of Ocular Disease in Animals</i> is an essential reference for veterinary ophthalmologists, veterinary pathologists, and residents in these areas.

Diese Produkte könnten Sie auch interessieren:

Biology, Medicine, and Surgery of Elephants
Biology, Medicine, and Surgery of Elephants
von: Murray Fowler, Susan K. Mikota
PDF ebook
195,99 €
Veterinary Laser Surgery
Veterinary Laser Surgery
von: Noel A. Berger, Peter H. Eeg
PDF ebook
122,99 €